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These brands contain the same active ingredient (Amantadine Hydrochloride). Same strength and form. Confirm the switch with your doctor or pharmacist.
Indications & Uses
Amadin is indicated for:
Pharmacology
Amantadine hydrochloride affects dopamine neurons both directly and indirectly. At the pre-synaptic membrane, it boosts dopamine release and blocks its reuptake. Post-synaptically, it acts directly on the dopamine receptor and up-regulates D2 receptors, an effect that may stem from amantadine-induced hypersensitivity of these receptors. The drug carries antimuscarinic properties as well.
Amantadine's antiglutamatergic action works through non-competitive antagonism of NMDA receptors. Potent, competitive NMDA receptor antagonists that are not subunit-selective can lessen the severity of levodopa-induced dyskinesias, and sensitization of NMDA receptors may be a key step in how these dyskinesias develop.
The drug is immunomodulatory too, restoring interleukin-2 (IL-2) production, which is deficient in people with Parkinson's disease.
How amantadine produces its antiviral effect is not fully understood. Its main action seems to be blocking the release of infectious viral nucleic acid into the host cell by interfering with the transmembrane domain of the viral M2 protein, and it is also thought to prevent virus assembly during replication. It does not interfere with the immunogenicity of inactivated influenza A virus vaccine.
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
Parkinson's disease, adults: The usual dose is 100 mg twice a day when used alone. The initial dose of Amantadine is 100 mg daily for patients with serious associated medical illnesses or who are receiving high doses of other antiparkinson drugs. After one to several weeks at 100 mg once daily, the dose may be increased to 100 mg twice daily, if necessary. Occasionally, patients whose responses are not optimal with Amantadine at 200 mg daily may benefit from an increase up to 400 mg daily in divided doses.
Dosage for concomitant therapy: Some patients who do not respond to anticholinergic antiparkinson drugs may respond to Amantadine. When Amantadine or anticholinergic antiparkinson drugs are each used with marginal benefit, concomitant use may produce additional benefit. When Amantadine and levodopa therapy are initiated concurrently, the patient can exhibit rapid therapeutic benefits. Amantadine dose should be held constant at 100 mg daily or twice daily while the daily dose of levodopa is gradually increased to optimal benefit. When Amantadine is added to optimal well tolerated doses of levodopa, additional benefit may result, including smoothing out the fluctuations in improvement which sometimes occur in patients on levodopa alone. Patients who require a reduction in their usual dose of levodopa because of development of side effects may possibly regain lost benefit with the addition of Amantadine.
Drug induced extrapyramidal reactions, adults: The usual dose is 100 mg twice a day. Occasionally, patients whose responses are not optimal with Amantadine at 200 mg daily may benefit from an increase up to 300 mg daily in divided doses.
Prophylaxis and treatment of Influenza A virus illness, adults: 200 mg a day as a single dose or 100 mg twice daily. If CNS effects develop on a once daily dosage, a split dosage schedule may reduce complaints. Elderly over 65 years of age: 100 mg every day. Children 1 to 9 years of age: 4.4 to 8.8 mg/kg/day, not to exceed 150 mg/day. Children 9 to 12 years of age: 100 mg twice daily.
Method of administration: Each capsule is to be taken orally either with or without food. Patients with renal impairment: The dose should be reduced. This can be achieved by either reducing the total daily dose, or by increasing the dosage interval in accordance with the creatinine clearance. Patients with hepatic impairment: Use with caution.
Side Effects
The side effects of Influ are usually mild, and if they do occur, they tend to ease up or go away after about a week or more of use. The most commonly reported issues are nausea, dizziness or lightheadedness, and difficulty sleeping. Less often, it may cause swelling in the ankles or a mottled, purplish skin discoloration known as livedo reticularis. Other possible effects include anxiety, a heightened or elevated mood, headache, tiredness, hallucinations, unsteady movement, slurred speech, blurred vision, trouble concentrating, nervousness, low mood, muscle aches, palpitations, a drop in blood pressure on standing, dry mouth, loss of appetite, constipation, and excessive sweating.
Cautions & Contraindications
Warnings & Precautions
Influ should not be stopped suddenly in patients with Parkinson's disease, since a few patients have experienced a parkinsonian crisis, meaning a sudden, marked clinical decline, when this medicine was stopped abruptly. If atropine-like effects appear when Influ is used together with anticholinergic drugs, the dose of either drug should be reduced. Stopping the medicine suddenly may also bring on delirium, agitation, delusions, hallucinations, paranoid reactions, stupor, anxiety, depression, and slurred speech.
Contraindications
Amantadine hydrochloride should not be used by anyone who has a known hypersensitivity to the active substance or to any of the excipients contained in the formulation.
Pregnancy & Breastfeeding
Pregnancy category C. There haven't been well-controlled studies looking at how safe amantadine is for pregnant women, so its risk profile in pregnancy remains unknown. It may still be used during pregnancy if the expected benefits are judged to outweigh this uncertain risk to the fetus. Small amounts of amantadine do pass into breast milk, and since no data exist on how this affects a nursing infant, it should be used with caution by breastfeeding mothers.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Overdose
Deaths have been reported after overdose with Amantadine Hydrochloride. The lowest acute lethal dose on record is 1 gram. Some patients have tried to end their lives by taking an overdose, so prescriptions should be written for the smallest quantity that still allows good patient management.
The acute toxicity may be due to the anticholinergic effects of Amantadine Hydrochloride. Overdose has caused toxicity in the heart, lungs, kidneys or central nervous system. Heart problems include arrhythmia, tachycardia and hypertension. Pulmonary edema and respiratory distress have been reported. Kidney problems can occur too, including increased BUN, decreased creatinine clearance and renal insufficiency. Central nervous system effects include insomnia, anxiety, agitation, aggressive behavior, hypertonia, hyperkinesia, ataxia, gait abnormality, tremor, confusion, disorientation, depersonalization, fear, delirium, hallucinations, psychotic reactions, lethargy, somnolence and coma. Seizures may get worse in patients who have a history of seizure disorders. Hyperthermia has also been seen.
There is no specific antidote for an Amantadine Hydrochloride overdose. Still, slowly given intravenous physostigmine has been reported to control the central nervous system toxicity. In an adult the doses are 1 and 2 mg at 1- to 2-hour intervals. In a child the dose is 0.5 mg at 5- to 10-minute intervals, up to a maximum of 2 mg/hour. For acute overdose, general supportive measures should be used along with immediate gastric lavage or induction of emesis. Fluids should be forced, and given intravenously if necessary.
The pH of the urine has been reported to affect how fast Amantadine Hydrochloride is excreted. The excretion rate rises rapidly when the urine is acidic, so urine acidifying drugs may increase elimination of the drug from the body. Blood pressure, pulse, respiration and temperature should be monitored. The patient should be watched for hyperactivity and convulsions, and if required, sedation and anticonvulsant therapy should be given. The patient should also be watched for arrhythmias and hypotension, and if required, appropriate antiarrhythmic and antihypotensive therapy should be given. Electrocardiographic monitoring may be required after ingestion, because malignant tachyarrhythmias can appear after overdose.
⚠️ In an emergency call 999 or go to the nearest hospital emergency department.
Storage
Keep Amantadine Hydrochloride out of the reach of children. Store it in a cool, dry place and protect it from light.
Drug Interactions
Common questions about Amadin 100 mg
What is Amadin 100 mg Capsule?
Amadin 100 mg Capsule is a medicine that contains Amantadine Hydrochloride. It is made by Kumudini Pharma Ltd. It belongs to the Respiratory viral infections (Influenza) group of medicines.
What is Amadin used for?
Amadin is used for: Parkinson's Disease, Viral Infection.
What are the side effects of Amadin?
The side effects of Influ are usually mild, and if they do occur, they tend to ease up or go away after about a week or more of use. The most commonly reported issues are nausea, dizziness or lightheadedness, and difficulty sleeping.
Can I take Amadin during pregnancy or while breastfeeding?
Pregnancy category C. There haven't been well-controlled studies looking at how safe amantadine is for pregnant women, so its risk profile in pregnancy remains unknown. Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
What happens if I take too much Amadin?
Deaths have been reported after overdose with Amantadine Hydrochloride. The lowest acute lethal dose on record is 1 gram. In an emergency call 999 or go to the nearest hospital emergency department.
How should I store Amadin?
Keep Amantadine Hydrochloride out of the reach of children. Store it in a cool, dry place and protect it from light.
Can I take other medicines with Amadin?
Some medicines can interact with Amantadine Hydrochloride, for example: Memantine Hydrochloride, Levodopa, Atropine Sulphate, Chlorthalidone, Pramipexole, Oxyphenonium Bromide. Tell your doctor or pharmacist about every medicine you take.
Do I need a prescription for Amadin?
Amadin is a prescription (Rx) medicine. Take it as your doctor advises.