More from Alfasin
Other strengths and forms by Incepta Pharmaceuticals Ltd.
Indications & Uses
Alfasin is indicated for:
Pharmacology
Alfuzosin hydrochloride works by selectively blocking post-synaptic α1-adrenoreceptors, which are found in the prostate, bladder base, bladder neck, prostatic capsule, and prostatic urethra. By binding competitively and selectively to these α1-adrenergic receptors in the lower urinary tract, it relaxes smooth muscle tone in the prostate, prostatic capsule, bladder neck, and proximal urethra. It also eases sympathetic nervous stimulation, lowers resting urethral pressure, and inhibits the sympathetic nervous stimulation caused by urethral hypertonia. Because it is uroselective, alfuzosin preferentially targets α1 receptors in the prostate; blocking these receptors reduces BPH symptoms, improves urine flow, and lowers the likelihood of hypertensive events.
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
Benign prostatic hyperplasia (BPH): the recommended dose is 10 mg of Alfuzosin Hydrochloride, taken once daily after a meal.
Acute urinary retention (AUR): in patients 65 years and older, 10 mg of Alfuzosin Hydrochloride is taken daily after a meal, starting from the first day of catheterisation. Treatment is given for 3 to 4 days in total: 2 to 3 days during catheterisation and 1 day after the catheter is removed. For this indication, no benefit has been shown in patients under 65 years of age or when treatment continues beyond 4 days.
The Alfuzosin Hydrochloride tablet should be swallowed whole.
Side Effects
Classification of expected frequencies: very common (<1/10), common (<1/100 to <1/10), uncommon (<1/1,000 to <1/100), rare (<1/10,000 to <1/1,000), very rare (<1/10,000), not known (cannot be estimated from the available data). Within each frequency group, the side effects of Alfuzosin Hydrochloride are listed in order of decreasing seriousness. Nervous system disorders: Common: faintness/dizziness, headache. Uncommon: syncope, vertigo, malaise, drowsiness. Eye disorders: Uncommon: vision abnormal. Not known: intraoperative floppy iris syndrome. Cardiac disorders: Uncommon: tachycardia, palpitations, hypotension (postural). Very rare: new onset, aggravation or recurrence of angina pectoris in patients with pre-existing coronary artery disease. Not known: atrial fibrillation. Vascular disorders: Uncommon: hypotension (postural), flushing. Blood and lymphatic system disorders: Not known: neutropenia, thrombocytopenia. Respiratory, thoracic and mediastinal disorders: Uncommon: rhinitis. Gastro-intestinal disorders: Common: nausea, abdominal pain. Uncommon: diarrhoea, dry mouth, vomiting. Not known: vomiting. Hepatobiliary disorders: Frequency unknown: hepatocellular injury, cholestatic liver disease. Skin and subcutaneous tissue disorders: Uncommon: rash, pruritus. Very rare: urticaria, angioedema. Reproductive system and breast disorders: Frequency unknown: priapism. General disorders and administration site conditions: Common: asthenia. Uncommon: flushes, oedema, chest pain.
Cautions & Contraindications
Warnings & Precautions
Alfasin XR should be used with caution when general anesthesia is planned, as it may lead to a marked drop in blood pressure during surgery. To reduce this risk, doctors generally advise stopping the tablets 24 hours beforehand. If chest pain (angina) appears or worsens while taking Alfasin XR, treatment should be discontinued.
Contraindications
As with all alpha-1-blockers, some people may get a drop in blood pressure when standing up, with or without symptoms such as dizziness, tiredness or sweating. This can happen within a few hours of taking the medicine, and it is more likely in people who are also taking blood pressure medicines or nitrates. If it happens, lie down until the symptoms have fully gone. These effects are temporary, usually show up at the start of treatment, and do not often stop people from carrying on. Make sure the patient knows that this may happen. Alfuzosin Hydrochloride should be used carefully in people with acute heart failure. The same applies to anyone who has had a strong drop in blood pressure after taking another alpha-1-blocker. Treatment should start slowly in people who are sensitive to alpha-1-blockers. Take care when giving Alfuzosin Hydrochloride to people already on blood pressure medicines. Blood pressure should be checked regularly, especially in the first part of treatment. People with congenital QTc prolongation, a known history of acquired QTc prolongation, or who are taking medicines known to lengthen the QTc interval should be checked before and during treatment with Alfuzosin Hydrochloride. In people with heart disease, the usual treatment for coronary insufficiency should go on. If angina pectoris comes back or gets worse, Alfuzosin Hydrochloride should be stopped. There is no clinical safety data for people with severe kidney impairment (creatinine clearance below 30 ml/min), so the Alfuzosin Hydrochloride 10 mg prolonged release tablets should not be given to this group. Patients must be told to swallow the tablet whole. Crunching, crushing, chewing, grinding or pounding it into powder is not allowed. Doing any of these can release and absorb the drug in the wrong way, which may bring on side effects early. Intraoperative Floppy Iris Syndrome (IFIS, a variant of small pupil syndrome) has been seen during cataract surgery in some people who are taking or have taken alpha-1-blockers. The risk with Alfuzosin Hydrochloride seems very low, but eye surgeons should be told before cataract surgery if the patient is taking or has taken any alpha-1-blocker, as IFIS can lead to more complications during the operation. The surgeon should be ready to change the surgical technique if needed. Alfuzosin Hydrochloride 10 mg prolonged release tablets contain hydrogenated castor oil, which may upset the stomach and cause diarrhoea.
Pregnancy & Breastfeeding
Not applicable, as this medicine is used only in men.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Use in Special Populations
Paediatric Population: Alfuzosin Hydrochloride has not been shown to work in children aged 2 to 16 years, so it is not indicated for children.
Overdose
If someone takes too much Alfuzosin Hydrochloride, they should be admitted to hospital and kept lying flat on their back. Low blood pressure (hypotension) is treated in the usual way. If the blood pressure drops significantly, the right corrective treatment may be a vasoconstrictor, a medicine that acts directly on the muscle fibres of the blood vessels.
⚠️ In an emergency call 999 or go to the nearest hospital emergency department.
Storage
Keep Alfuzosin Hydrochloride in a cool, dry place and away from light.
Drug Interactions
Common questions about Alfasin 10 mg
What is Alfasin 10 mg Er Tablet?
Alfasin 10 mg Er Tablet is a medicine that contains Alfuzosin Hydrochloride. It is made by Incepta Pharmaceuticals Ltd. It belongs to the BPH/ Urinary retention/ Urinary incontinence group of medicines.
What is Alfasin used for?
Alfasin is used for: Benign Prostatic Hyperplasia.
What are the side effects of Alfasin?
Classification of expected frequencies: very common (<1/10), common (<1/100 to <1/10), uncommon (<1/1,000 to <1/100), rare (<1/10,000 to <1/1,000), very rare (<1/10,000), not known (cannot be estimated from the available data). Within each frequency group, the side effects of Alfuzosin Hydrochloride are listed in order of decreasing seriousness.
Can I take Alfasin during pregnancy or while breastfeeding?
Not applicable, as this medicine is used only in men. Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
What happens if I take too much Alfasin?
If someone takes too much Alfuzosin Hydrochloride, they should be admitted to hospital and kept lying flat on their back. Low blood pressure (hypotension) is treated in the usual way. In an emergency call 999 or go to the nearest hospital emergency department.
How should I store Alfasin?
Keep Alfuzosin Hydrochloride in a cool, dry place and away from light.
Can I take other medicines with Alfasin?
Some medicines can interact with Alfuzosin Hydrochloride, for example: Atenolol, Hydrochlorothiazide, Digoxin, Itraconazole, Ritonavir, Ketoconazole. Tell your doctor or pharmacist about every medicine you take.
Do I need a prescription for Alfasin?
Alfasin is a prescription (Rx) medicine. Take it as your doctor advises.