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Other brands with the same active ingredient
These brands contain the same active ingredient (Alendronic Acid). Same strength and form. Confirm the switch with your doctor or pharmacist.
Indications & Uses
Alendon 70 is indicated for:
Pharmacology
Alendronate is a bisphosphonate that binds to bone hydroxyapatite and specifically inhibits the activity of osteoclasts, the bone-resorbing cells. Alendronate reduces bone resorption with no direct effect on bone formation, although the latter process is ultimately reduced because bone resorption and formation are coupled during bone turnover.
Animal studies have indicated the following mode of action. At the cellular level, alendronate shows preferential localization to sites of bone resorption, specifically under osteoclasts. The osteoclasts adhere normally to the bone surface but lack the ruffled border that is indicative of active resorption. Alendronate does not interfere with osteoclast recruitment or attachment, but it does inhibit osteoclast activity. Studies in mice on the localization of radioactive [3H] alendronate in bone showed about 10 fold higher uptake on osteoclast surfaces than on osteoblast surfaces. Bones examined 6 and 49 days after [3H] alendronate administration in rats and mice, respectively, showed that normal bone was formed on top of the alendronate, which was incorporated inside the matrix. While incorporated in bone matrix, alendronate is not pharmacologically active. Thus, alendronate must be continuously administered to suppress osteoclasts on newly formed resorption surfaces. Histomorphometry in baboons and rats showed that alendronate treatment reduces bone turnover (that is, the number of sites at which bone is remodeled). In addition, bone formation exceeds bone resorption at these remodeling sites, leading to progressive gains in bone mass.
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
Treatment of osteoporosis in postmenopausal women: The recommended dose is one 70 mg tablet taken once a week, or one bottle of the 70 mg oral solution once a week, or one 10 mg tablet taken once daily.
Prevention of osteoporosis in postmenopausal women: The recommended dose is one 35 mg tablet once a week, or one 5 mg tablet once daily.
Treatment to increase bone mass in men with osteoporosis: The recommended dose is one 70 mg tablet once a week, or one bottle of the 70 mg oral solution once a week, or one 10 mg tablet once daily.
Treatment of glucocorticoid-induced osteoporosis: The recommended dose is one 5 mg tablet once daily. The exception is postmenopausal women not receiving estrogen, who should take one 10 mg tablet once daily instead.
Treatment of Paget's disease of bone: The recommended regimen is 40 mg once daily for six months.
Side Effects
Common side effects include constipation, diarrhoea, oesophageal ulcer, flatulence, difficulty swallowing, muscle and joint pain, and headache. Less often, patients may notice rash, redness of the skin, a brief drop in blood calcium and phosphate levels, nausea, vomiting, peptic ulcer, or allergic reactions such as hives and swelling (angio-oedema).
Cautions & Contraindications
Warnings & Precautions
Upper gastrointestinal adverse reactions can occur with alendronic acid, so patients should be told to follow the dosing instructions closely. If new or worsening symptoms appear, stop the medicine. Hypocalcemia can get worse on treatment, and it must be corrected before alendronic acid is started. Severe bone, joint and muscle pain may occur. If severe symptoms develop, stop using it. Osteonecrosis of the jaw has been reported. Atypical femur fractures have also been reported, so any patient with new thigh or groin pain should be evaluated to rule out an incomplete femoral fracture.
Contraindications
Alendronic acid should not be used by patients with abnormalities of the esophagus that delay esophageal emptying, such as stricture or achalasia, or by those who are unable to stand or sit upright for at least 30 minutes. The oral solution should not be given to patients at increased risk of aspiration. It is also contraindicated in patients with hypocalcemia and in those with hypersensitivity to any component of the product, as hypersensitivity reactions including urticaria and angioedema have been reported.
Pregnancy & Breastfeeding
Alendronic acid should not be given to pregnant women or to mothers who are breastfeeding.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Use in Special Populations
Pediatric Use
Alendronic Acid is not indicated for use in pediatric patients.
Renal Impairment
Alendronic Acid is not recommended for patients with creatinine clearance less than 35 mL/min. No dosage adjustment is needed for patients whose creatinine clearance is between 35 to 60 mL/min.
Hepatic Impairment
No studies were done in patients with hepatic impairment, because there is evidence that alendronate is not metabolized or excreted in the bile. No dosage adjustment is needed.
Storage
Keep Alendronic Acid in a well-closed container at room temperature, between 15 and 30°C.
Drug Interactions
Common questions about Alendon 70 70 mg
What is Alendon 70 70 mg Tablet?
Alendon 70 70 mg Tablet is a medicine that contains Alendronic Acid. It is made by Beximco Pharmaceuticals Ltd. It belongs to the Bisphosphonate preparations group of medicines.
What is Alendon 70 used for?
Alendon 70 is used for: Osteoporosis.
What are the side effects of Alendon 70?
Common side effects include constipation, diarrhoea, oesophageal ulcer, flatulence, difficulty swallowing, muscle and joint pain, and headache. Less often, patients may notice rash, redness of the skin, a brief drop in blood calcium and phosphate levels, nausea, vomiting, peptic ulcer, or allergic reactions such as hives and swelling (angio-oedema).
Can I take Alendon 70 during pregnancy or while breastfeeding?
Alendronic acid should not be given to pregnant women or to mothers who are breastfeeding. Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
How should I store Alendon 70?
Keep Alendronic Acid in a well-closed container at room temperature, between 15 and 30°C.
Can I take other medicines with Alendon 70?
Some medicines can interact with Alendronic Acid, for example: Aspirin. Tell your doctor or pharmacist about every medicine you take.
Do I need a prescription for Alendon 70?
Alendon 70 is a prescription (Rx) medicine. Take it as your doctor advises.