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Same active ingredient — pay up to 69% less
These brands contain the same active ingredient (Pheniramine Maleate). Same strength and form. Confirm the switch with your doctor or pharmacist.
Indications & Uses
Alarzil is indicated for:
Pharmacology
Pheniramine competes with histamine for the H1 receptor and behaves as an inverse agonist once it binds. This drop in H1 receptor activity is what reduces itching, and it also lessens vasodilation and capillary leakage, which in turn means less redness and swelling. This effect shows up clearly as suppression of the histamine-induced wheal (swelling) and flare (vasodilation) response. Inverse agonism at H1 receptors in the CNS is also what causes the drowsiness typical of first-generation antihistamines such as pheniramine. Pheniramine can also bind to H4 receptors and act as an inverse agonist there too, which may further ease itching by curbing inflammation.
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
Doses must always be worked out for each individual patient and should be taken with food or shortly afterwards. Treatment should begin at the lowest possible dose, since experience has shown that antihistamines are often effective at low doses. The maximum dose of 3 mg/kg per day must not be exceeded. Elderly patients should use the adult dose with caution. To prevent travel sickness, it is recommended that the first dose be taken at least 30 minutes before setting off. Because of the risk of drowsiness, patients should not drive a motor vehicle or operate machinery after taking a dose. For Pheniramine Maleate tablets, adults and children over 10 years of age should start with half a tablet taken up to three times daily, and this may be increased to one tablet up to three times daily if needed. Children aged 5 to 10 years should take half a tablet up to three times daily. Pheniramine Maleate tablets are not recommended for children under 5 years of age.
Side Effects
The most common side effect is drowsiness, which often fades after a few days as the body gets used to the medicine. Allergic reactions have been reported. Nervous system: Tiredness, dizziness, ringing in the ears, difficulty concentrating, poor coordination, irritability, sleeplessness and tremors. After an overdose, agitation and convulsions are common, especially in children, while restlessness, confusion and hallucinations are common in adults. Stomach and bowel: Nausea, vomiting, diarrhoea, cramping pain, pain in the upper abdomen, loss of appetite, dry mouth and constipation. Urinary: Difficulty passing urine. Heart and circulation: Palpitations and headache. Eyes: Blurred vision and raised pressure inside the eye. Muscles: Muscle weakness. Blood: Rare cases of blood disorders, including agranulocytosis (a severe drop in white blood cells) and haemolytic anaemia, have been reported.
Cautions & Contraindications
Warnings & Precautions
Alervil may cause drowsiness. In patients whose activities call for special concentration (for example, driving a car or operating machinery), both the dose and the timing of administration should be considered carefully. Patients should be warned not to take alcohol or other central nervous system (CNS) depressants at the same time. In toxic doses, Alervil may possibly be hallucinogenic. Because antihistamines can have CNS stimulating effects, pheniramine has the potential for abuse. Owing to the anticholinergic effect of pheniramine, caution and close monitoring are required when it is used in patients with conditions such as prostatic hypertrophy, narrow angle glaucoma, asthma or severe cardiovascular disease. The anti-emetic effect of pheniramine may mask the signs of other conditions. Products containing pheniramine should not be taken on an empty stomach.
Contraindications
Pheniramine should not be given to people with hypersensitivity to pheniramine or any other ingredient (for example, methyl hydroxybenzoate or propyl hydroxybenzoate in the syrup), to people with symptomatic prostatic hypertrophy, to people receiving MAO inhibitor therapy, or to newborn and premature infants.
Pregnancy & Breastfeeding
Pregnancy Category A. Should be used only when clearly indicated.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Overdose
Symptoms: In toxic doses, antihistamine drugs like pheniramine maleate cause a mix of CNS excitatory and depressant effects. Small children who have swallowed them by accident have had convulsions, and some have died.
Management: There is no specific antidote, so treatment is symptomatic and supportive. Vomiting should be induced only straight after ingestion. Any antihistamine that has been absorbed is sedating, and that can lead to life-threatening pulmonary aspiration during vomiting. Gastric lavage with a cuffed endotracheal tube in place may still help for some time after ingestion, because the anticholinergic action of antihistamines slows gastric emptying. Stimulants should not be used, as they may precipitate convulsions. Diazepam or short-acting barbiturates can be used to control convulsions, and vasopressors can be used to treat hypotension. If respiration is seriously depressed, mechanical support of respiration may be needed. If cardiac toxicity develops, continuous ECG monitoring is recommended, and the toxicity can be treated with centrally-acting anticholinesterases such as physostigmine.
⚠️ In an emergency call 999 or go to the nearest hospital emergency department.
Storage
Keep Pheniramine Maleate in a cool, dry place and away from light. Don't use it after the expiry date. Keep it, like all medicines, out of the reach of children. It should be dispensed only on the prescription of a registered physician.
Drug Interactions
Common questions about Alarzil 22.7 mg
What is Alarzil 22.7 mg Tablet?
Alarzil 22.7 mg Tablet is a medicine that contains Pheniramine Maleate. It is made by Pharmik Laboratories Ltd. It belongs to the Sedating Anti-histamine group of medicines.
What is Alarzil used for?
Alarzil is used for: Allergic Rhinitis, Fever, Vertigo, Nausea and Vomiting, Diabetes Mellitus, Eczema, Urticaria, Allergy, Conjunctivitis, Edema.
What are the side effects of Alarzil?
The most common side effect is drowsiness, which often fades after a few days as the body gets used to the medicine. Allergic reactions have been reported.
Can I take Alarzil during pregnancy or while breastfeeding?
Pregnancy Category A. Should be used only when clearly indicated. Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
What happens if I take too much Alarzil?
Symptoms: In toxic doses, antihistamine drugs like pheniramine maleate cause a mix of CNS excitatory and depressant effects. Small children who have swallowed them by accident have had convulsions, and some have died. In an emergency call 999 or go to the nearest hospital emergency department.
How should I store Alarzil?
Keep Pheniramine Maleate in a cool, dry place and away from light. Don't use it after the expiry date.
Can I take other medicines with Alarzil?
Some medicines can interact with Pheniramine Maleate, for example: Atropine Sulphate. Tell your doctor or pharmacist about every medicine you take.
Is there a cheaper medicine with the same ingredient?
Amarin by Opsonin Pharma Limited has the same ingredient and strength for ৳0.47 per unit, compared with ৳1.50 for Alarzil. Ask your doctor or pharmacist before switching.
Do I need a prescription for Alarzil?
Alarzil is a prescription (Rx) medicine. Take it as your doctor advises.