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Same active ingredient — pay up to 30% less
These brands contain the same active ingredient (Agomelatine). Same strength and form. Confirm the switch with your doctor or pharmacist.
Indications & Uses
Agotin is indicated for:
Pharmacology
Agomelatine works on melatonin and serotonin receptors in the brain. It acts as an agonist at the MT1 and MT2 melatonin receptors and as an antagonist at the 5-HT2C serotonin receptor. Binding studies show that agomelatine does not affect monoamine uptake. It also has no affinity for alpha 1, alpha 2 and beta 3 adrenergic receptors, histaminergic, cholinergic, dopaminergic or benzodiazepine receptors.
In animal models of circadian rhythm disruption, agomelatine resynchronises the body clock. Its effect on the brain's chemistry is quite specific. It increases the release of noradrenaline and dopamine in the frontal cortex, but it has no influence on the extracellular levels of serotonin.
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
The usual adult dose of agomelatine is 25 mg once a day, taken at bedtime. Taking it at night suits most people because agomelatine improves sleep quality without causing daytime drowsiness. You can take it with or without food. Most adults take one 25 mg tablet each day, usually just before bed. If you notice no improvement after two weeks, your doctor may increase the dose to 50 mg (two tablets) daily. The increase is for people who don't respond well to the lower dose, so don't raise it on your own.
Use in children and adolescents
Agomelatine should be given to anyone under 18 only on medical advice. It is not recommended for treating depression in patients under 18, because its safety and effectiveness have not been established in this age group. In clinical trials, children and adolescents taking other antidepressants showed more suicide-related behaviour (suicide attempts and suicidal thoughts) and more hostility (mostly aggression, oppositional behaviour and anger) than those given a placebo.
Use in the elderly
Agomelatine (25 to 50 mg per day) has been shown to work and to be safe in older patients with major depressive disorder (MDD) aged under 75 years. Its effectiveness has not been established in patients aged 75 and over, so agomelatine should not be used in that group.
Side Effects
The side effects most often reported in clinical trials of Agorest are headache, nausea and diarrhoea. Agomelatine can raise liver enzyme levels, so liver enzymes should be checked before treatment begins and then every 6 weeks during treatment. It must not be used in patients with hepatic impairment. A meta-analysis of treatment-emergent sexual dysfunction with antidepressants found no significant difference between agomelatine and placebo.
Cautions & Contraindications
Warnings & Precautions
Use caution before starting treatment, and monitor all patients closely throughout the treatment period, especially if risk factors for liver injury are present or if the patient is taking other medicines associated with a risk of liver injury. Baseline liver function tests should be carried out in all patients, and treatment should not be started in patients whose baseline ALT and/or AST levels are more than 3 times the upper limit of normal. Agorest should be used with caution in elderly patients (75 years and older), as clinical data in this group are lacking. Agorest should not be used to treat major depressive episodes in elderly patients with dementia, since its safety and efficacy have not been established in these patients. Agorest is not recommended for the treatment of depression in patients under 18 years of age. Agorest should be used with caution in patients with a history of bipolar disorder, mania or hypomania.
Contraindications
Agomelatine must not be used in people who are hypersensitive to the active substances or to any of the excipients. It is also contraindicated in hepatic impairment (i.e. cirrhosis or active liver disease), or when transaminases exceed 3 times the upper limit of normal. It should not be taken together with potent CYPIA2 inhibitors (eg. Fluvoxamine, ciprofloxacin).
Pregnancy & Breastfeeding
Use in pregnancy: There's no clinical data yet on how agomelatine affects pregnant women, since human exposure hasn't been formally studied. Animal studies, however, haven't shown any direct or indirect harm to pregnancy, foetal or embryonal development, delivery, or development after birth. Even so, agomelatine should be prescribed to pregnant women only with caution.
Use in lactation: Whether agomelatine passes into human breast milk isn't known, though it and its breakdown products have been found in the milk of nursing rats. Because its effects on a breastfeeding baby haven't been established, breastfeeding should be stopped if treatment with agomelatine is judged necessary.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Overdose
Experience with Agomelatine overdose is limited. During clinical development, a few overdoses were reported, either with Agomelatine alone (up to 450 mg) or together with other psychotropic medicines (up to 525 mg). The signs and symptoms were limited and included drowsiness and epigastralgia.
No specific antidote for Agomelatine is known. Treatment of an overdose should deal with the clinical symptoms and include routine monitoring. Medical follow-up in a specialised environment is recommended.
⚠️ In an emergency call 999 or go to the nearest hospital emergency department.
Storage
Agomelatine should be dispensed only on the prescription of a registered physician. Store it in a cool, dry place below 30°C and keep it away from light. Keep it out of the reach of children.
Drug Interactions
Common questions about Agotin 25 mg
What is Agotin 25 mg Tablet?
Agotin 25 mg Tablet is a medicine that contains Agomelatine. It is made by Beacon Pharmaceuticals PLC. It belongs to the Atypical anti-depressant drugs group of medicines.
What is Agotin used for?
Agotin is used for: Depression.
What are the side effects of Agotin?
The side effects most often reported in clinical trials of Agorest are headache, nausea and diarrhoea. Agomelatine can raise liver enzyme levels, so liver enzymes should be checked before treatment begins and then every 6 weeks during treatment.
Can I take Agotin during pregnancy or while breastfeeding?
Use in pregnancy: There's no clinical data yet on how agomelatine affects pregnant women, since human exposure hasn't been formally studied. Animal studies, however, haven't shown any direct or indirect harm to pregnancy, foetal or embryonal development, delivery, or development after birth. Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
What happens if I take too much Agotin?
Experience with Agomelatine overdose is limited. During clinical development, a few overdoses were reported, either with Agomelatine alone (up to 450 mg) or together with other psychotropic medicines (up to 525 mg). In an emergency call 999 or go to the nearest hospital emergency department.
How should I store Agotin?
Agomelatine should be dispensed only on the prescription of a registered physician. Store it in a cool, dry place below 30°C and keep it away from light.
Can I take other medicines with Agotin?
Some medicines can interact with Agomelatine, for example: Ciprofloxacin, Fluvoxamine Maleate. Tell your doctor or pharmacist about every medicine you take.
Is there a cheaper medicine with the same ingredient?
Agorest by Everest Pharmaceuticals Ltd. has the same ingredient and strength for ৳35.00 per unit, compared with ৳50.15 for Agotin. Ask your doctor or pharmacist before switching.
Do I need a prescription for Agotin?
Agotin is a prescription (Rx) medicine. Take it as your doctor advises.