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Indications & Uses
Abeclib is indicated for:
Pharmacology
Abemaciclib blocks two enzymes called cyclin-dependent kinases 4 and 6 (CDK4 and CDK6). These kinases switch on when they bind to D-cyclins. In estrogen receptor-positive (ER+) breast cancer cell lines, cyclin D1 and CDK4/6 drive phosphorylation of the retinoblastoma protein (Rb), and this pushes the cell cycle forward and makes the cells multiply.
In vitro, continuous exposure to abemaciclib inhibited Rb phosphorylation. It also stopped cells from moving from G1 into S phase of the cell cycle, and this led to senescence and apoptosis. In breast cancer xenograft models, abemaciclib given daily without interruption, either as a single agent or together with antiestrogens, reduced tumor size.
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
Abemaciclib tablets are swallowed by mouth, and you can take them with or without food. When abemaciclib is given together with fulvestrant, tamoxifen or an aromatase inhibitor, the recommended starting dose is 150 mg twice daily. When it is used on its own as monotherapy, the recommended starting dose is 200 mg twice daily. The doctor may need to pause the treatment or lower the dose, depending on how safe and well tolerated it is for the individual patient.
Side Effects
The most common side effects of abemaciclib, seen in at least 20% of people, were diarrhea, neutropenia, nausea, abdominal pain, infections, fatigue and anemia. Leukopenia, decreased appetite, vomiting, headache, alopecia and thrombocytopenia were also reported at that rate.
Cautions & Contraindications
Warnings & Precautions
Diarrhoea: Abemaciclib can cause severe diarrhoea, linked with dehydration and infection. Tell patients to start an anti-diarrhoeal medicine at the first sign of loose stools, drink more fluids and let their doctor know. Neutropenia: Check complete blood counts before starting Abemaciclib, then every 2 weeks for the first 2 months, monthly for the next 2 months, and whenever clinically indicated. Interstitial Lung Disease (ILD)/Pneumonitis: Severe and fatal cases of ILD/pneumonitis have been reported. Watch for clinical symptoms or radiological changes that point to ILD/pneumonitis. Stop Abemaciclib permanently in all patients with Grade 3 or 4 ILD or pneumonitis. Hepatotoxicity: Serum transaminase levels have been seen to rise. Do liver function tests (LFTs) before starting treatment with Abemaciclib. Then repeat them every two weeks for the first two months, monthly for the next 2 months, and as clinically indicated. Venous Thromboembolism: Watch patients for signs and symptoms of thrombosis and pulmonary embolism, and treat as medically appropriate. Embryo-Fetal Toxicity: Abemaciclib can cause fetal harm. Advise patients of the potential
Pregnancy & Breastfeeding
Abemaciclib can harm an unborn baby if a pregnant woman takes it. This is based on animal studies and on how the medicine works. In pregnant rats, giving abemaciclib during the period when the organs form caused malformations (teratogenicity) and lower fetal weight. The mother's exposure in those studies was similar to the exposure seen in people at the maximum recommended human dose, measured by area under the curve (AUC).
Pregnant women should be told about the possible risk to the baby. Women who could become pregnant should use effective contraception while they are on Abemaciclib and for 3 weeks after the last dose.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Use in Special Populations
Pediatric use: The safety and effectiveness of Abemaciclib haven't been established in pediatric patients.
Geriatric use: In older patients, no overall differences in safety or effectiveness of Abemaciclib were seen compared with younger patients.
Renal impairment: Patients with mild or moderate renal impairment don't need a dosage adjustment.
Hepatic impairment: Patients with mild or moderate hepatic impairment don't need any dosage adjustment.
Storage
Store Abemaciclib below 30°C, and keep it away from light and moisture. Keep it out of the reach of children.
Drug Interactions
Common questions about Abeclib 200 mg
What is Abeclib 200 mg Tablet?
Abeclib 200 mg Tablet is a medicine that contains Abemaciclib. It is made by Eskayef Pharmaceuticals Ltd. It belongs to the Protein kinase inhibitor group of medicines.
What is Abeclib used for?
Abeclib is used for: Cancer.
What are the side effects of Abeclib?
The most common side effects of abemaciclib, seen in at least 20% of people, were diarrhea, neutropenia, nausea, abdominal pain, infections, fatigue and anemia. Leukopenia, decreased appetite, vomiting, headache, alopecia and thrombocytopenia were also reported at that rate.
Can I take Abeclib during pregnancy or while breastfeeding?
Abemaciclib can harm an unborn baby if a pregnant woman takes it. This is based on animal studies and on how the medicine works. Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
How should I store Abeclib?
Store Abemaciclib below 30°C, and keep it away from light and moisture. Keep it out of the reach of children.
Can I take other medicines with Abeclib?
Some medicines can interact with Abemaciclib, for example: Ketoconazole. Tell your doctor or pharmacist about every medicine you take.
Is there a cheaper medicine with the same ingredient?
Abeclib is already among the lowest-priced brands of Abemaciclib at this strength.
Do I need a prescription for Abeclib?
Abeclib is a prescription (Rx) medicine. Take it as your doctor advises.