Save on this medicine
Other brands with the same active ingredient
These brands contain the same active ingredient (Abiraterone Acetate). Same strength and form. Confirm the switch with your doctor or pharmacist.
Indications & Uses
Zyterone Tablet 250 mg is indicated for:
Pharmacology
Abiraterone Acetate is converted in the body to Abiraterone, which blocks androgen biosynthesis by inhibiting 17 α-hydroxylase/C17, 20-lyase (CYP17). This enzyme is found in testicular, adrenal and prostatic tumour tissue, and it is needed to make androgens. CYP17 carries out two reactions one after the other: 1. Pregnenolone and progesterone are converted to their 17 α-hydroxy derivatives by 17 α-hydroxylase activity. 2. Dehydroepiandrosterone (DHEA) and androstenedione are then formed, respectively, by C17, 20 lyase activity. DHEA and androstenedione are androgens, and they are also precursors of testosterone.
When Abiraterone inhibits CYP17, the adrenals can also produce more mineralocorticoids. Androgen sensitive prostatic carcinoma responds to treatment that lowers androgen levels. Androgen deprivation therapies, such as GnRH agonists or orchiectomy, reduce androgen production in the testes. They do not affect androgen production by the adrenals or within the tumour.
In the placebo-controlled clinical trial, Abiraterone Acetate lowered serum testosterone and other androgens in patients. You don't need to monitor its effect on serum testosterone levels. Serum prostate specific antigen (PSA) levels may change, but these changes have not been shown to match clinical benefit in individual patients.
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
Recommended Dose for Metastatic CRPC: The recommended dose of Abiraterone Acetate is 1,000 mg (two 500 mg tablets or four 250 mg tablets) taken by mouth once daily along with Prednisone 5 mg taken by mouth twice daily. Recommended Dose for Metastatic High Risk CSPC: The recommended dose of Abiraterone Acetate is 1,000 mg (two 500 mg tablets or four 250 mg tablets) taken by mouth once daily along with Prednisone 5 mg taken by mouth once daily. Patients receiving Abiraterone Acetate should also receive a gonadotropin releasing hormone (GnRH) analog at the same time or should have had bilateral orchiectomy. Abiraterone Acetate must be taken on an empty stomach, at least one hour before or at least two hours after a meal. The tablets should be swallowed whole with water. Do not crush or chew the tablets. Dose Modification: For patients with baseline moderate hepatic impairment (Child Pugh Class B), the Abiraterone Acetate starting dose should be reduced to 250 mg once daily. For patients who develop hepatotoxicity during treatment, Abiraterone Acetate should be held until recovery, and retreatment may then be started at a reduced dose. Abiraterone Acetate should be discontinued if patients develop severe hepatotoxicity. Concomitant use of strong CYP3A4 inducers, such as Phenytoin, Carbamazepine, Rifampin, Rifabutin, Rifapentine, and Phenobarbital, should be avoided during Abiraterone Acetate treatment. If a strong CYP3A4 inducer must be given at the same time, the Abiraterone Acetate dosing frequency should be increased to twice a day only during the period of co administration, for example, from 1,000 mg once daily to 1,000 mg twice a day. Once the concomitant strong CYP3A4 inducer is stopped, the dose should be reduced back to the previous dose and frequency. Or, as directed by the registered physician. Pediatric Use: The safety and effectiveness of Abiraterone Acetate in pediatric patients have not been established.
Side Effects
The most common side effects include tiredness, joint pain, high blood pressure, nausea, swelling (edema), low potassium levels, hot flushes, diarrhea, vomiting, upper respiratory infections, cough, and headache.
Cautions & Contraindications
Warnings & Precautions
Zyterone can raise blood pressure, lower potassium levels, and cause fluid retention, since it increases mineralocorticoid levels through CYP17 inhibition. Patients should have their blood pressure, potassium, and fluid status checked at least once a month. Hypertension and low potassium should be brought under control and corrected both before treatment begins and throughout its course. Patients should also be watched for symptoms and signs of adrenocortical insufficiency. Serum transaminases (ALT and AST) and bilirubin should be checked before starting Zyterone, every two weeks for the first three months of treatment, and monthly after that.
Contraindications
Hypersensitivity to abiraterone acetate or to any of the excipients contained in this medicine.
Pregnancy & Breastfeeding
Abiraterone has not been shown to be safe or effective in females. Animal studies and the way the medicine works both point to the same risk: abiraterone can harm an unborn baby and may lead to loss of the pregnancy. There are no human data on its use in pregnant women.
The safety and efficacy of Abiraterone have not been established in females. As for breastfeeding, there is no information on whether abiraterone acetate passes into human milk, or on what effect it might have on a breastfed child or on milk production.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Overdose
There's no specific antidote for an Abiraterone Acetate overdose. If it happens, stop the medicine and give general supportive care. This includes watching for arrhythmias and cardiac failure, and checking how well the liver is working.
⚠️ In an emergency call 999 or go to the nearest hospital emergency department.
Storage
Store Abiraterone Acetate at no more than 25°C. Protect it from light. Keep it out of the reach of children.
Drug Interactions
Common questions about Zyterone Tablet 250 mg 250 mg
What is Zyterone Tablet 250 mg 250 mg Tablet?
Zyterone Tablet 250 mg 250 mg Tablet is a medicine that contains Abiraterone Acetate. It is made by Healthcare Pharmaceuticals Ltd. It belongs to the Cytotoxic Chemotherapy group of medicines.
What is Zyterone Tablet 250 mg used for?
Zyterone Tablet 250 mg is used for: Cancer.
What are the side effects of Zyterone Tablet 250 mg?
The most common side effects include tiredness, joint pain, high blood pressure, nausea, swelling (edema), low potassium levels, hot flushes, diarrhea, vomiting, upper respiratory infections, cough, and headache.
Can I take Zyterone Tablet 250 mg during pregnancy or while breastfeeding?
Abiraterone has not been shown to be safe or effective in females. Animal studies and the way the medicine works both point to the same risk: abiraterone can harm an unborn baby and may lead to loss of the pregnancy. Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
What happens if I take too much Zyterone Tablet 250 mg?
There's no specific antidote for an Abiraterone Acetate overdose. If it happens, stop the medicine and give general supportive care. In an emergency call 999 or go to the nearest hospital emergency department.
How should I store Zyterone Tablet 250 mg?
Store Abiraterone Acetate at no more than 25°C. Protect it from light.
Can I take other medicines with Zyterone Tablet 250 mg?
Some medicines can interact with Abiraterone Acetate, for example: Pioglitazone, Rifampicin, Dextromethorphan Hydrobromide. Tell your doctor or pharmacist about every medicine you take.
Do I need a prescription for Zyterone Tablet 250 mg?
Zyterone Tablet 250 mg is a prescription (Rx) medicine. Take it as your doctor advises.