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Other brands with the same active ingredient
These brands contain the same active ingredient (Ziprasidone). Same strength and form. Confirm the switch with your doctor or pharmacist.
Indications & Uses
Zipsydon is indicated for:
Pharmacology
Ziprasidone's action in the listed indications is thought to result from a combination of antagonism at dopamine type 2 (D2) and serotonin type 2 (5HT2) receptors. The drug binds with relatively high affinity to dopamine D2 and D3 receptors, serotonin 5HT2A, 5HT2C, 5HT1A, and 5HT1D receptors, and α1-adrenergic receptors (Ki values of 4.8, 7.2, 0.4, 1.3, 3.4, 2, and 10 nM, respectively), and with moderate affinity to the histamine H1 receptor (Ki=47 nM). It acts as an antagonist at the D2, 5HT2A, and 5HT1D receptors, and as an agonist at the 5HT1A receptor. Ziprasidone also inhibits synaptic reuptake of serotonin and norepinephrine. It showed no appreciable affinity for the other receptor and binding sites tested, including the cholinergic muscarinic receptor (IC50 greater than 1 µM).
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
Administer capsules by mouth with food, and do not open, crush, or chew them.
For schizophrenia: begin at 20 mg twice daily. The daily dose may be adjusted up to 80 mg twice daily, with adjustments made no more often than every 2 days. Doses up to 100 mg twice daily have been shown to be safe and effective, but the lowest effective dose should always be used.
For acute treatment of manic or mixed episodes of bipolar I disorder: begin at 40 mg twice daily, increasing to 60 mg or 80 mg twice daily on the second day of treatment. Further adjustments should be guided by tolerability and response, within a range of 40 mg to 80 mg twice daily.
For maintenance treatment of bipolar I disorder as an add on to lithium or valproate: continue at the same dose at which the patient was originally stabilized, within a range of 40 mg to 80 mg twice daily.
For acute treatment of agitation associated with schizophrenia, given by intramuscular injection: 10 mg to 20 mg as needed, up to a maximum of 40 mg per day. A 10 mg dose may be repeated every 2 hours, and a 20 mg dose may be repeated every 4 hours.
Side Effects
Commonly reported side effects (occurring in 5% or more of patients and at least twice as often as with placebo) included the following. For schizophrenia: sleepiness and respiratory tract infection. For manic and mixed episodes associated with bipolar disorder: sleepiness, extrapyramidal symptoms, dizziness, akathisia, abnormal vision, weakness, and vomiting. For intramuscular administration (occurring in 5% or more of patients and at least twice as often as in the lowest-dose intramuscular Zipradon group): headache, nausea, and sleepiness.
Cautions & Contraindications
Warnings & Precautions
Cerebrovascular Adverse Reactions in Elderly Patients with Dementia-Related Psychosis Elderly patients with dementia-related psychosis have a higher rate of cerebrovascular adverse reactions, such as stroke and transient ischemic attack. QT Interval Prolongation Zipradon should be avoided in patients with bradycardia, hypokalemia or hypomagnesemia, or congenital prolongation of the QT interval. It should also be avoided when it is taken with other drugs that have been shown to prolong the QT interval. Neuroleptic Malignant Syndrome (NMS) A potentially fatal group of symptoms has been reported with antipsychotic drugs. If this happens, stop the drug straight away and monitor the patient closely. Severe Cutaneous Adverse Reactions Serious skin reactions, including Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) and Stevens-Johnson syndrome, have been reported with Zipradon. DRESS and other Severe Cutaneous Adverse Reactions (SCAR) are sometimes fatal, so stop Zipradon if DRESS or SCAR is suspected. Tardive Dyskinesia This movement disorder may develop suddenly or over a long period. Metabolic Changes Atypical antipsychotic drugs have been linked to metabolic changes that may raise the risk of cardiovascular and cerebrovascular problems. These changes include high blood sugar, abnormal blood fats (dyslipidemia) and weight gain. Hyperglycemia and Diabetes Mellitus (DM) Watch every patient for signs of high blood sugar, such as excessive thirst, frequent urination, increased hunger and weakness. Patients with risk factors for diabetes should have their blood glucose tested before starting treatment and during treatment. Dyslipidemia Unwanted changes in blood fats have been seen in patients taking atypical antipsychotics. Weight Gain Weight gain has been reported, so keep track of the patient's weight. Rash If a patient develops a rash and the cause is not known, stop the drug. Orthostatic Hypotension Use with caution in patients who already have cardiovascular or cerebrovascular disease. Leukopenia, Neutropenia and Agranulocytosis These blood problems have been reported with antipsychotics. Patients who already have a low white blood cell (WBC) count, or who have had leukopenia or neutropenia before, should have their complete blood count (CBC) checked often during the first few months of treatment. If the WBC count starts to fall and no other cause is found, stop Zipradon at once. Seizures Use cautiously in patients who have had seizures before or who have conditions that lower the seizure threshold. Cognitive and Motor Impairment Patients should be careful when operating machinery, as the drug can affect thinking and movement. Suicide Keep a close watch on high-risk patients.
Contraindications
Do not use ziprasidone in patients with a known history of QT prolongation, a recent acute myocardial infarction, or uncompensated heart failure. It should also be avoided in combination with other drugs known to prolong the QT interval, and in anyone with known hypersensitivity to ziprasidone.
Storage
Keep below 30°C temperature, away from light & moisture. Keep out of the reach of children.
Drug Interactions
Common questions about Zipsydon 20 mg
What is Zipsydon 20 mg Capsule?
Zipsydon 20 mg Capsule is a medicine that contains Ziprasidone. It is made by Sun Pharmaceutical (Bangladesh) Ltd. It belongs to the Atypical neuroleptic drugs group of medicines.
What is Zipsydon used for?
Zipsydon is used for: Schizophrenia.
What are the side effects of Zipsydon?
Commonly reported side effects (occurring in 5% or more of patients and at least twice as often as with placebo) included the following. For schizophrenia: sleepiness and respiratory tract infection.
How should I store Zipsydon?
Keep below 30°C temperature, away from light & moisture. Keep out of the reach of children.
Can I take other medicines with Zipsydon?
Some medicines can interact with Ziprasidone, for example: Ivabradine. Tell your doctor or pharmacist about every medicine you take.
Do I need a prescription for Zipsydon?
Zipsydon is a prescription (Rx) medicine. Take it as your doctor advises.