Pricing
Prices are indicative MRP and may vary by pharmacy. Trend compares against the last recorded price.
All price changes →Save on this medicine
Same active ingredient — pay up to 13% less
These brands contain the same active ingredient (Duloxetine Hydrochloride). Strength and form may differ — confirm substitution with your doctor or pharmacist before switching.
Indications & Uses
Xinolax DR is indicated for:
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
Major Depressive Disorder (MDD)- Starting Dose: 40 mg/day to 60 mg/day Target Dose: Acute: 40 mg/day (20 mg twice daily) to 60 mg/day (once daily or as 30 mg twice daily); Maintenance: 60 mg/day Maximum Dose: 120 mg/day Generalized Anxiety Disorder (GAD)- Starting Dose: 60 mg/day Target Dose: 60 mg/day (once daily) Maximum Dose: 120 mg/day Diabetic Peripheral Neuropathic Pain (DPNP)- Starting Dose: 60 mg/day Target Dose: 60 mg/day (once daily) Maximum Dose: 60 mg/day Fibromyalgia- Starting Dose: 30 mg/day Target Dose: 60 mg/day (once daily) Maximum Dose: 60 mg/day Chronic Musculoskeletal Pain- Starting Dose: 30 mg/day Target Dose: 60 mg/day (once daily) Maximum Dose: 60 mg/day Some patients may benefit from starting at 30 mg once daily. There is no evidence that doses greater than 60 mg/day confers an additional benefit, while some adverse reactions were observed to be dose-dependent. A gradual dose reduction is recommended to avoid discontinuation symptoms.
Side Effects
The most commonly observed adverse events in Duloxen treated patients were nausea, dizziness, dry mouth, constipation, decreased appetite, fatigue, somnolence, increased sweating, hyperhidrosis and asthenia. It may slightly increase blood pressure. No clinically significant differences were observed for QT, PR, and QRS intervals between Duloxen-treated and placebo-treated patients.
Cautions & Contraindications
Warnings & Precautions
All patients being treated with antidepressants for any indication should be monitored appropriately and observed closely for clinical worsening, suicidality and unusual changes in behavior, especially during the initial few months of a course of drug therapy, or at times of dose changes. Blood pressure should be measured prior to initiating treatment and periodically measured throughout treatment. Patients should be cautioned about the risk of bleeding associated with the concomitant use of Duloxen and NSAIDs, aspirin, or other drugs that affect coagulation. Duloxen should be used cautiously in patients with a history of mania. Duloxen should be prescribed with care in patients with a history of a seizure disorder.
Contraindications
Duloxetine is contraindicated in patients with a known hypersensitivity to this drug or any of the inactive ingredients. Duloxetine is not approved for use in treating bipolar depression. Duloxetine should not be prescribed to patients with substantial alcohol use or evidence of chronic liver disease. In clinical trials, Duloxetine was associated with an increased risk of mydriasis; therefore, it should be used cautiously in patients with controlled narrow-angle glaucoma.