Pricing
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All price changes →Indications & Uses
Vitilen is indicated for:
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
Dosage Methoxsalen capsules:Vitiligo therapy: Two Methoxsalen capsules (10 mg each) in one dose taken with milk or food two to four hours before ultraviolet light exposure.Light exposure: The exposure time to sunlight should comply with the following guide: Initial exposure: Light-15 min, Medium-20 min, Dark-25 min Second exposure: Light-20 min, Medium-25 min, Dark-30 min Third exposure: Light-25 min, Medium-30 min, Dark-35 min Fourth exposure: Light-30 min, Medium-35 min, Dark-40 min Subsequent exposure: Gradually increase exposure based on erythema and tenderness of the amelanotic skin. Therapy should be on alternate days and never two consecutive days.Psoriasis therapy: The Methoxsalen capsules should be taken 2 hours before UVA exposure with some food or milk, according to the following table: <30 kg body weight: 10 mg 30-50 kg body weight: 20 mg 51-65 kg body weight: 30 mg 66-80 kg body weight: 40 mg 81-90 kg body weight: 50 mg 91-115 kg body weight: 60 mg >115 kg body weight: 70 mg Methoxsalen Lotion: is applied to a well-defined area of vitiligo by the physician and the area is then exposed to a suitable credit of UVA. Initial exposure time should be conservative and not exceed that which is predicted to be one-half the minimal erythema dose. Treatment intervals should be regulated by the erythema response; generally once a week is recommended or less often depending on results. The hands and fingers of the person applying the medication should be protected by gloves or finger cots to avoid photosensitization and possible burns.Pigmentation may begin after a few weeks but significant repigmentation may require 6 to 9 months of treatment. Periodic re-treatment may be necessary to retain all of the new pigment. Idiopathic vitiligo is reversible but not equally reversible in every patient. Treatment must be individualized. Repigmentation will vary in completeness, time of onset, and duration. Repigmentation occurs more rapidly in fleshy areas such as face, abdomen, and buttocks and less rapidly over less fleshy areas such as the dorsum of the hands or feet.Pediatric use: Safety in children has not been established.
Side Effects
Vitilen most commonly causes nausea, affecting around 10% of patients. This can usually be reduced or avoided by taking the medicine with milk or food, or by splitting the dose into two portions given about half an hour apart. Other reported effects include nervousness, insomnia, and psychological depression.
Cautions & Contraindications
Warnings & Precautions
Skin burning: Serious burns from UVA or from sunlight, even through window glass, can occur if the recommended dosage and exposure schedule are not carefully followed. Carcinogenicity: The risk of carcinoma appears higher among patients who are fair skinned or who have had prior PUVA exposure or prolonged treatment with tar UVB, ionizing radiation, or arsenic. Cataractogenicity: Among patients who use proper eye protection, there is no evidence of a significantly increased risk of cataracts with PUVA therapy. Patients must not sunbathe during the 24 hours before taking Vitilen and before UV exposure.
Contraindications
Patients with idiosyncratic reactions to psoralen compounds should not use this medicine. It is also not recommended for those with light-sensitive conditions such as lupus erythematosus, porphyria, erythropoietic protoporphyria, variegate porphyria, xeroderma pigmentosum or albinism, as well as patients with melanoma or a history of melanoma, invasive squamous cell carcinoma, or aphakia.