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Other brands with the same active ingredient
These brands contain the same active ingredient (Dantrolene Sodium). Same strength and form. Confirm the switch with your doctor or pharmacist.
Indications & Uses
Trolen-25 is indicated for:
Pharmacology
Dantrolene works by relaxing skeletal muscle at a point beyond the nerve-muscle junction, acting directly on the muscle fibre itself. Within the muscle, it breaks the link between electrical excitation and contraction, most likely by interfering with the release of calcium ions from the sarcoplasmic reticulum.
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
For use in chronic spasticity, adults: the following gradual titration schedule is suggested. Some patients will not respond until a higher daily dosage is achieved. Each dosage level should be maintained for seven days to determine the patient's response. If no further benefit is observed at the next higher dose, the dosage should be decreased to the previous lower dose. The starting dose is 25 mg twice per day, and it can be increased by 25 to 50 mg per day each week. The maximum accepted dosage is 400 mg per day.
Paediatric patients: the following gradual titration schedule is suggested. Some patients will not respond until a higher daily dosage is achieved. Each dosage level should be maintained for seven days to determine the patient's response. If no further benefit is observed at the next higher dose, the dosage should be decreased to the previous lower dose. Give 0.5 mg/kg once daily for seven days, then 0.5 mg/kg 3 times daily for 7 days, then 1 mg/kg 3 times daily for 7 days, then 2 mg/kg 3 times a day. Therapy with a dose 4 times daily may be necessary for some individuals.
For malignant hyperthermia, preoperatively: administer 4 to 8 mg/kg/day of oral Dantrolene in 3 or 4 divided doses for one or two days prior to surgery, with the last dose given approximately 3 to 4 hours before the scheduled surgery with a minimum of water.
Post crisis follow-up: oral Dantrolene should also be administered following a malignant hyperthermia crisis, in doses of 4 to 8 mg/kg per day in four divided doses, for a one to three day period to prevent recurrence of the manifestations of malignant hyperthermia.
Side Effects
The most common side effects of Relaxo are drowsiness, dizziness, weakness, a general feeling of being unwell, tiredness, and diarrhoea. These are usually short-lived, tend to occur early in treatment, and can often be avoided by starting on a low dose and increasing it gradually until the right regimen is found. Diarrhoea may be severe and may require Relaxo to be stopped for a time. If diarrhoea returns when Relaxo is restarted, treatment should probably be stopped permanently.
Cautions & Contraindications
Warnings & Precautions
Because Relaxo can damage the liver with long-term use, treatment should be stopped if no benefit is seen within 45 days. Patients should be warned not to drive or take part in hazardous work while taking Relaxo. Care is needed when tranquilizers are given at the same time. Relaxo may cause a photosensitivity reaction, so patients should be warned about sunlight exposure while taking it. It is important to recognize that fatal and non-fatal liver disorders of an idiosyncratic or hypersensitivity type may occur with Relaxo treatment. When starting Relaxo, liver function tests (SGOT, SGPT, alkaline phosphatase, total bilirubin) should be done to set a baseline or to find out whether liver disease is already present. Liver function tests (e.g., SGOT or SGPT) should be repeated at appropriate intervals during treatment. In some patients these values have returned to normal despite continued treatment; in others they have not. If symptoms suggesting hepatitis appear together with abnormal liver function tests or jaundice, Relaxo should be stopped. When caused by Relaxo and detected early, these liver abnormalities have typically returned to normal after the drug was stopped. Relaxo has been restarted in a few patients who developed clinical and/or laboratory evidence of liver cell injury. Restarting should be attempted only in patients who clearly need Relaxo, and only after the earlier symptoms and laboratory abnormalities have cleared. The patient should be admitted to hospital and the drug restarted at very small, gradually increasing doses. Laboratory monitoring should be frequent, and the drug should be withdrawn immediately at any sign that the liver is affected again. Relaxo should be used with particular caution in women and in patients over 35 years of age, as drug-induced, potentially fatal liver cell disease appears more likely in these groups. It should also be used with caution in patients with impaired lung function, in patients with severely impaired heart function due to heart muscle disease, and in patients with a history of liver disease or abnormal liver function.
Contraindications
Active liver disease, such as hepatitis or cirrhosis.
Pregnancy & Breastfeeding
Pregnancy Category C. Dantrolene capsules should only be used during pregnancy if the potential benefit is thought to outweigh the potential risk to the unborn baby. Dantrolene should not be used by mothers who are breastfeeding.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Use in Special Populations
Usage in Paediatric Patients
The long-term safety of Dantrolene Sodium has not been established in children under 5 years of age. Some adverse effects of the medicine may only show up after many years, so the benefit and the risk of long-term use need to be weighed with particular care in paediatric patients.
Storage
Store in a cool & dry place, protected from light.
Drug Interactions
Common questions about Trolen-25 25 mg
What is Trolen-25 25 mg Capsule?
Trolen-25 25 mg Capsule is a medicine that contains Dantrolene Sodium. It is made by Drug International Ltd., Gopalpur. It belongs to the Centrally acting Skeletal Muscle Relaxants group of medicines.
What is Trolen-25 used for?
Trolen-25 is used for: Stroke, Muscle Spasm, Cancer.
What are the side effects of Trolen-25?
The most common side effects of Relaxo are drowsiness, dizziness, weakness, a general feeling of being unwell, tiredness, and diarrhoea. These are usually short-lived, tend to occur early in treatment, and can often be avoided by starting on a low dose and increasing it gradually until the right regimen is found.
Can I take Trolen-25 during pregnancy or while breastfeeding?
Pregnancy Category C. Dantrolene capsules should only be used during pregnancy if the potential benefit is thought to outweigh the potential risk to the unborn baby. Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
How should I store Trolen-25?
Store in a cool & dry place, protected from light.
Can I take other medicines with Trolen-25?
Some medicines can interact with Dantrolene Sodium, for example: Memantine Hydrochloride. Tell your doctor or pharmacist about every medicine you take.
Do I need a prescription for Trolen-25?
Trolen-25 is a prescription (Rx) medicine. Take it as your doctor advises.