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These brands contain the same active ingredient (Sulphamethoxazole + Trimethoprim). Strength and form may differ — confirm substitution with your doctor or pharmacist before switching.
Triprim DS
Rx800 mg+160 mg • Tablet
Indications & Uses
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
Cotrimoxazole double strength tablet: over 12 years. For mild to moderate infections, take 1 tablet twice daily. For severe infections, take 1.5 tablets twice daily. For long term therapy of more than 14 days, take 0.5 tablet twice daily. For gonorrhoea, take 2 tablets every 12 hours for two days, or 2.5 tablets followed by a further dose of 2.5 tablets after 8 hours. Cotrimoxazole tablet: over 12 years. For mild to moderate infections, take 2 tablets twice daily. For severe infections, take 2 tablets thrice daily. For long term therapy of more than 14 days, take 1 tablet twice daily. Cotrimoxazole suspension: under 12 years. For 6 to 12 years, take 2 teaspoonfuls twice daily. For 6 months to 5 years, take 1 teaspoonful twice daily. For 6 weeks to 6 months, take 0.5 teaspoonful twice daily.
Side Effects
Sulphamethoxazole-Trimethoprim is generally well tolerated. Rare but reported side effects include crystalluria, allergic reactions, haemolysis, thrombocytopenia, neutropenia, and agranulocytosis. Milder effects such as malaise, headache, nausea, and vomiting may occur, but these are usually temporary and do not usually call for stopping treatment.
Cautions & Contraindications
Warnings & Precautions
Prolonged treatment with full doses of sulfamethoxazole-trimethoprim can lead to macrocytic anaemia, since the combination interferes with the conversion of folic acid to folinic acid. Should this occur, giving folinic acid will reverse it. In diabetic patients on a sulphonylurea drug, Sitrim should be used with caution, as it may potentiate the sulphonylurea's action.
Contraindications
Hypersensitivity to trimethoprim or to sulphonamide medicines rules out this drug, as does a confirmed diagnosis of megaloblastic anaemia caused by folate deficiency. It should also be avoided in patients with marked liver damage, blood disorders, severe kidney impairment, or glucose-6-phosphate dehydrogenase (G6PD) deficiency.