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Other brands with the same active ingredient
These brands contain the same active ingredient (Topiramate). Strength and form may differ — confirm substitution with your doctor or pharmacist before switching.
Indications & Uses
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
Epilepsy, monotherapy, adults and children over 16 years: Titration should begin at 25 mg nightly for 1 week. The dosage should then be increased at 1 or 2 week intervals by increments of 25 or 59 mg/day, given in two divided doses. The recommended initial target dose for topiramate monotherapy in adults with newly diagnosed epilepsy is 100 mg/day, and the maximum recommended daily dose is 400 mg. Children aged 6 to 16 years: Treatment of children aged 6 years and above should begin at 0.5 to 1 mg/kg nightly for the first week. The dosage should then be increased at 1 or 2 week intervals by increments of 0.5 to 1 mg/kg/day, given in two divided doses. The recommended initial target dose range for topiramate monotherapy in children with newly diagnosed epilepsy aged 6 years and above is 3 to 6 mg/kg/day. Higher doses have been tolerated, and rarely doses up to 16 mg/kg/day have been given. Epilepsy, adjunctive therapy, adults and children over 16 years: The minimal effective dose as adjunctive therapy is 200 mg per day. The usual total daily dose is 200 mg to 400 mg in two divided doses. Some patients may require doses up to 800 mg per day, which is the maximum recommended dose. Children aged 2 to 16 years: The recommended total daily dose of topiramate as adjunctive therapy is approximately 5 to 9 mg/kg/day in two divided doses. Titration should begin at 25 mg nightly for the first week. The dosage should then be increased at 1 or 2 week intervals by increments of 1 to 3 mg/kg/day, given in two divided doses, to achieve optimal clinical response. Dose titration should be guided by clinical outcome. Daily doses up to 30 mg/kg/day have been studied and were generally well tolerated. Migraine, adults and children over 16 years: Titration should begin at 25 mg nightly for 1 week. The dosage should then be increased in increments of 25 mg/day, administered at 1 week intervals. The recommended total daily dose of topiramate for the prophylaxis of migraine headache is 100 mg/day, given in two divided doses. Some patients may experience benefit at a total daily dose of 50 mg/day. Children: Topiramate for migraine prophylaxis has not been studied in children under 16 years.
Side Effects
Nausea, abdominal pain, dyspepsia, diarrhoea, dry mouth, taste disturbance, weight loss, anorexia, paraesthesia, hypoaesthesia, headache, fatigue, dizziness, speech disorder, drowsiness, insomnia, impaired memory & concentration, anxiety, depression, visual disturbance, lesscommonly: sucidal ideation, rarely: reduced sweetening mainly children, metabolic acidosis and alopecia, very rarely: Leucopenia, thrombocytopenia and serious skin reaction.
Cautions & Contraindications
Warnings & Precautions
In patients with or without a history of seizures or epilepsy, antiepileptic drugs, including Topirva XR, should be gradually withdrawn to minimize the potential for seizures or increased seizure frequency. Topirva XR can produce central nervous system related adverse events and may be more sedative than other antiepileptic drugs. Drowsiness is a likelihood. In addition, there have been reports of visual disturbances and blurred vision. Patients should be warned of these effects and advised that if affected, they should not drive, operate machinery, or take part in activities where such reactions could put themselves or others at risk.
Contraindications
Hypersensitivity to topiramate or to any other ingredient in this product.