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These brands contain the same active ingredient (Levothyroxine Sodium). Strength and form may differ — confirm substitution with your doctor or pharmacist before switching.
Indications & Uses
Thyronor is indicated for:
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
Adult dose: The initial starting dose is usually 25 to 50 mcg per day, with gradual increases at intervals of 6 to 8 weeks as needed. The Levothyroxine Sodium dose is generally adjusted in steps of 12.5 to 25 mcg until the patient with primary hypothyroidism is clinically euthyroid and the serum TSH level has returned to normal. In patients with severe hypothyroidism, the initial dose is 12.5 to 25 mcg per day, with increases of 25 mcg per day every 2 to 4 weeks, along with clinical and laboratory assessment, until the TSH level is normal. In patients with secondary (pituitary) or tertiary (hypothalamic) hypothyroidism, the Levothyroxine Sodium dose should be adjusted until the patient is clinically euthyroid and the serum free T4 level is restored to the upper half of the normal range. For patients older than 50 years, or patients under 50 years of age with underlying heart disease, the dose is 1.7 mcg per kg per day. Pediatric dosage for newborns: the recommended starting dose is 10 to 15 mcg per kg per day. A lower starting dose should be considered in infants at risk of heart failure, and the dose should be increased every 4 to 6 weeks as needed based on the clinical and laboratory response to treatment. In infants with very low serum T4 concentration (below 5 mcg per dL) or an undetectable level, the recommended initial starting dose is 50 mcg per day of Levothyroxine Sodium. Pediatric dosage for infants and children: in children with chronic or severe hypothyroidism, the initial dose is 25 mcg per day, with increases of 25 mcg every 2 to 4 weeks until the desired effect is achieved. Hyperactivity in an older child can be reduced if the starting dose is one fourth of the recommended full replacement dose, with the dose then increased weekly by an amount equal to one fourth of the full recommended replacement dose, until the full recommended replacement dose is reached. From 0 to 3 months, the dose is 10 to 15 mcg per kg per day. From 3 to 6 months, it is 8 to 10 mcg per kg per day. From 6 to 12 months, it is 6 to 8 mcg per kg per day. From 1 to 5 years, it is 5 to 6 mcg per kg per day. From 6 to 12 years, it is 4 to 5 mcg per kg per day. Over 12 years but with growth and puberty not yet complete, it is 2 to 3 mcg per kg per day. Once growth and puberty are complete, it is 1.7 mcg per kg per day. The dose should be adjusted based on the patient's clinical response and laboratory parameters.
Side Effects
Adverse reactions linked to Synthox therapy are mainly those of hyperthyroidism brought on by therapeutic overdose. They include the following: General: fatigue, increased appetite, weight loss, heat intolerance, fever, excessive sweating. Central nervous system: headache, hyperactivity, nervousness, anxiety, irritability, emotional lability, insomnia. Musculoskeletal: tremors, muscle weakness. Cardiovascular: palpitations, tachycardia, arrhythmias, increased pulse and blood pressure. Respiratory: dyspnea. Gastrointestinal: diarrhea, vomiting, abdominal cramps. Dermatologic: hair loss, flushing.
Cautions & Contraindications
Warnings & Precautions
In patients whose hypothyroidism is due to a decrease in pituitary gland function, there may also be adrenocortical insufficiency;before starting Synthox therapy, this should be treated by adequate replacement with Corticosteroids to prevent acute adrenal insufficiency. The choice of the starting dose and of any increases in dosing should be made with great care in patients with cardiovascular disease and/or severe and long-existing hypothyroidism.Too high an initial dose or too rapid an increase in dosing may lead to development or worsening of angina complaints, arrhythmias, myocardial infarction, cardiac failure or to sudden increase in blood pressure, especially in older patients. Any marked change of body weight during treatment with T4 requires adjustment of the dosage. When monitoring blood levels of T3 and T4, it should be borne in mind that a "high" normal to slightly increased T4 level will be necessary in order to obtain a normal level of T3. The correct dosage of Synthox in primary hypothyroidism should generally be established by monitoring the serum level of TSH to see whether it has normalized. Because intoxication with Thyroid preparations may have serious consequences.
Contraindications
Untreated subclinical or overt Thyrotoxicosis of any etiology Acute Myocardial Infarction Uncorrected Adrenal failure.