Pricing
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All price changes →Indications & Uses
Thiotab is used together with sodium nitrite, given one after the other, to treat acute cyanide poisoning that is considered life-threatening. It should be used with caution when the diagnosis of cyanide poisoning is not certain.
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
Adults: Give after 300 mg of sodium nitrite has been administered over 5 to 20 minutes. The dose is 12.5 g of sodium thiosulfate (50 ml of a 25% solution or 25 ml of a 50% solution), given over 10 minutes. The methaemoglobin concentration should not exceed 30 to 40%. If symptoms of cyanide toxicity return, the doses of nitrite and thiosulfate may be repeated after 30 minutes at half the initial doses. Children: Give after 4 to 10 mg/kg of sodium nitrite (maximum 300 mg) has been administered. The dose is 400 mg/kg of sodium thiosulfate, as a 25% or 50% solution (maximum 12.5 g). The methaemoglobin concentration should not exceed 30 to 40%. If symptoms of cyanide toxicity return, the doses of nitrite and thiosulfate may be repeated after 30 minutes at half the initial doses.
Side Effects
Osmotic disturbances may occur. Orally, high doses can cause catharsis.
Cautions & Contraindications
Warnings & Precautions
Thiotab may contain trace impurities of sodium sulfite. The presence of a trace amount of sulfites in Thiotab should not deter administration of the drug in emergency situations, even if the patient is sulfite-sensitive.