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Same active ingredient — pay up to 50% less
These brands contain the same active ingredient (Amlodipine Besilate + Olmesartan Medoxomil). Same strength and form. Confirm the switch with your doctor or pharmacist.
More from Tenivasc
Other strengths and forms by Unimed Unihealth Pharmaceuticals Ltd.
Indications & Uses
Tenivasc is indicated for:
Pharmacology
Amlodipine is a dihydropyridine calcium channel blocker that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle. Amlodipine has a greater effect on vascular smooth muscle cells than on cardiac muscle cells. Amlodipine is a peripheral arterial vasodilator that acts directly on vascular smooth muscle to cause a reduction in peripheral vascular resistance and reduction in blood pressure.Angiotensin II formed from angiotensin I in a reaction catalyzed by angiotensin-converting enzyme (ACE), is a potent vasoconstrictor, the primary vasoactive hormone of the Renin-angiotensin system and an important component in the pathophysiology of hypertension. It also stimulates aldosterone secretion by the adrenal cortex. Olmesartan Medoxomil blocks the vasoconstrictor and aldosterone-secreting effects of angiotensin II by selectively blocking the binding of angiotensin II to the AT1 receptor found in many tissues, (e.g. vascular smooth muscle, adrenal gland). In vitro binding studies indicate that Olmesartan Medoxomil is a reversible, competitive inhibitor of the AT1 receptor. Olmesartan Medoxomil does not inhibit ACE (kinase II, the enzyme that converts angiotensin I to angiotensin II and degrades bradykinin).
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
Substitute individually titrated components for patients on Amlodipine and Olmesartan Medoxomil. This combination may also be given with increased amounts of Amlodipine, Olmesartan Medoxomil, or both, as needed.Initial therapy: Initiate with 5/20 mg once daily for 1 to 2 weeks and titrate as needed up to a maximum of 10/40 mg once daily. Due to decreased clearance of Amlodipine among elderly patients the recommended starting dose of Amlodipine is 2.5 mg in patients 75 years. The lowest dose of the combination is 5/20 mg; therefore, initial therapy with this combination drug is not recommended in patients >75 years old.
Side Effects
The most common side effects include peripheral edema, headache, flushing, and dizziness. It can also cause Intestinal problems known a sprue-like enteropathy.
Cautions & Contraindications
Warnings & Precautions
Amlodipine and Olmesartan Medoxomil combination should be used with caution because there is a risk for- Hypotension in volume- or salt depleted patients. Vasodilation in patients with severe aortic stenosis. Increased frequency, duration or severity of angina or acute Ml in patients with severe obstructive coronary artery disease.
Contraindications
Cannot be co-administered with Aliskiren in patients with diabetes.
Pregnancy & Breastfeeding
Pregnancy Category D. Amlodipine and Olmesartan Medoxomil combination should not be used in 2nd and 3rd trimester because it can cause fetal death. When pregnancy is detected this combination should be discontinued as soon as possible. It is not known whether Olmesartan and Amlodipine are excreted in human milk. Because of the potential for adverse effects on the nursing infant, a decision should be made whether to discontinue nursing or discontinue the drug, taking into account the importance of the drug to the mother.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Use in Special Populations
Pediatric use: The safety and effectiveness have not been established in pediatric patients.
Geriatric use: No overall differences in safety or effectiveness were observed between subjects 65 years of age or older and younger subjects.
Renal impairment: There are no studies in patients with renal impairment.
Hepatic impairment: Initial therapy is not recommended in hepatically impaired patients.
Overdose
There is no information on over dosage in humans.
⚠️ In an emergency call 999 or go to the nearest hospital emergency department.
Storage
Do not store above 30°C. Keep away from light and out of the reach of children.
Drug Interactions
Common questions about Tenivasc 5 mg+20 mg
What is Tenivasc 5 mg+20 mg Tablet?
Tenivasc 5 mg+20 mg Tablet is a medicine that contains Amlodipine Besilate + Olmesartan Medoxomil. It is made by Unimed Unihealth Pharmaceuticals Ltd. It belongs to the Combined antihypertensive preparations group of medicines.
What is Tenivasc used for?
Tenivasc is used for: Hypertension.
What are the side effects of Tenivasc?
The most common side effects include peripheral edema, headache, flushing, and dizziness. It can also cause Intestinal problems known a sprue-like enteropathy.
Can I take Tenivasc during pregnancy or while breastfeeding?
Pregnancy Category D. Amlodipine and Olmesartan Medoxomil combination should not be used in 2nd and 3rd trimester because it can cause fetal death. Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
What happens if I take too much Tenivasc?
There is no information on over dosage in humans. In an emergency call 999 or go to the nearest hospital emergency department.
How should I store Tenivasc?
Do not store above 30°C. Keep away from light and out of the reach of children.
Can I take other medicines with Tenivasc?
Some medicines can interact with Amlodipine Besilate + Olmesartan Medoxomil, for example: Olmesartan Medoxomil. Tell your doctor or pharmacist about every medicine you take.
Is there a cheaper medicine with the same ingredient?
Olmenor AM by Delta Pharma PLC. has the same ingredient and strength for ৳5.00 per unit, compared with ৳10.00 for Tenivasc. Ask your doctor or pharmacist before switching.
Do I need a prescription for Tenivasc?
Tenivasc is a prescription (Rx) medicine. Take it as your doctor advises.