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These brands contain the same active ingredient (Sulphadoxine + Pyrimethamine). Strength and form may differ — confirm substitution with your doctor or pharmacist before switching.
Indications & Uses
Sulfamin is indicated for:
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
Curative treatment of malaria with a single dose- Adults: 2-3 tablets Children under 4 years: ½ tablets 4-8 years: 1 tablet 9-14 years: 2 tablets In severe cases, Sulphadoxine & Pyrimethamine can be beneficially combined with quinine. Suppressive or prophylactic management- The dose given below should be taken at one time:For semi-immune subjects (Dose: once every four weeks)- Adults: 2-3 tablets Children under 4 years: ½ tablets 4-8 years: 1 tablet 9-14 years: 2 tablets For non-immune subjects (Dose: Once every two weeks)- Adults: 2 tablets Children under 4 years: 1½ tablets 4-8 years: 1 tablet 9-14 years: 1½ tablets For malaria prophylaxis: The first dose of Sulphadoxine & Pyrimethamine should be taken one or two days before departure for an endemic area in order to protect tolerance, administration should be continued in the above dosage during the stay and also for four weeks after return or as prescribed by the physician.
Side Effects
Sulphadoxine & Pyrimethamine at the recommended dose is well tolerated. Main side effects are given below Skin reactions: Drug rash, pruritus and slight hair loss have been observed. Gastro-intestinal reactions: Feeling of fullness, nausea, rarely vomiting, stomatitis. Haematological reactions: In rare cases, leukopenia, thrombocytopenia, and megaloblastic anemia have been observed. Other reactions: Fatigue, headache, fever, polyneuritis may occasionally occur.
Cautions & Contraindications
Warnings & Precautions
Impaired renal or hepatic function, folate deficiency, severe allergy or bronchial asthma, G6PD deficiency, pregnancy. Take with plenty of water to prevent crystalluria. Avoid excessive exposure to sun. Discontinue at the first sign of rash. Discontinue if signs of folic acid deficiency develops. Regular CBC monitoring, LFT, analysis of urine for crystalluria when admin for > 3 mth. Take with food to minimise Gi effects (e.g. anorexia and vomiting).
Contraindications
Prophylactic (repeated) use of Pyrimethamine + Sulphadoxine is contraindicated in patients with severe renal insufficiency, marked liver parenchymal damage or blood dyscrasias. Treatment must be immediately discontinued upon the appearance of any mucocutaneous signs or symptoms such as pruritus, erythema, rash, orogenital lesions or pharyngitis.