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Other strengths and forms by Opsonin Pharma Limited
Indications & Uses
Pharmacology
Cefuroxime is a well-studied, effective antibacterial with broad-spectrum bactericidal activity against a wide range of common pathogens, including strains that produce β-lactamase. Because it resists breakdown by bacterial β-lactamase, it remains active against many strains that are resistant to ampicillin and amoxycillin.
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
Dosage Tablet or Suspension. Adolescents and adults (13 years and older): for pharyngitis or tonsillitis, 250 mg twice daily for 5 to 10 days. Acute bacterial maxillary sinusitis: 250 mg twice daily for 10 days. Acute bacterial exacerbation of chronic bronchitis: 250 to 500 mg twice daily for 10 days. Secondary bacterial infections of acute bronchitis: 250 to 500 mg twice daily for 5 to 10 days. Uncomplicated skin and skin structure infections: 250 to 500 mg twice daily for 10 days. Uncomplicated urinary tract infections: 250 mg twice daily for 7 to 10 days. Uncomplicated gonorrhoea: 1000 mg as a single dose. Community acquired pneumonia: 250 to 500 mg twice daily for 5 to 10 days. MDR typhoid fever: 500 mg twice daily for 10 to 14 days. Early Lyme disease: 500 mg twice daily for 20 days.
Paediatric patients (3 months to 12 years): for pharyngitis or tonsillitis, 20 mg/kg/day in two divided doses for 5 to 10 days. Acute otitis media: 30 mg/kg/day in two divided doses for 10 days. Acute bacterial maxillary sinusitis: 30 mg/kg/day in two divided doses for 10 days. Impetigo: 30 mg/kg/day in two divided doses for 10 days.
Parenteral. Adult: 750 mg three times daily by IM or IV injection. In severe infections, the dose can be increased up to 1.5 gm three times daily by IV injection. The frequency may be increased to four times daily if necessary, giving total daily doses of 3 to 6 gms. Children above 3 months of age: 30 to 100 mg/kg/day given in 3 or 4 equally divided doses. A dose of 60 mg/kg/day is appropriate for most infections. Neonate: 30 to 100 mg/kg/day given in 2 or 3 equally divided doses. Surgical prophylaxis: 1.5 gm by IV injection at induction of anaesthesia, with up to 3 further doses of 750 mg given by IV or IM injection every 8 hours for high risk procedures. Pneumonia: 1.5 gm by IV injection twice daily for 2 to 3 days, followed by 500 mg twice daily by mouth for 7 to 10 days. Acute exacerbations of chronic bronchitis: 750 mg twice daily by IM or IV injection for 2 to 3 days, followed by 500 mg twice daily by mouth for 5 to 10 days. The duration of both parenteral and oral therapy is determined by the severity of the infection and the clinical status of the patient.
In gonorrhoea, adults are given 1.5 gm as a single dose, as two 750 mg injections given intramuscularly at different sites, such as each buttock.
In meningitis, adults are given 3 gm by IV injection three times daily. Children above 3 months of age: 200 to 240 mg/kg/day by IV injection in 3 or 4 divided doses, reduced to 100 mg/kg/day after 3 days or on clinical improvement. Neonate: an initial dose of 100 mg/kg/day by IV injection, reduced to 50 mg/kg/day when clinically indicated.
In bone and joint infections, adults are given 1.5 gm by IV injection four times daily. Children above 3 months of age: 150 mg/kg/day, not to exceed the maximum adult dose, in equally divided doses every 8 hours.
Side Effects
Adverse reactions to Xitil have not been common, and when they do occur, they tend to be mild and short-lived. Skin rashes and stomach or bowel upset have been reported. As with other antibiotics, using this medicine for a long period can allow organisms that don't respond to it, such as Candida, to grow unchecked.
Cautions & Contraindications
Warnings & Precautions
Xitil should be used cautiously in patients on concurrent treatment with potent diuretics, as well as in those with a history of colitis. Cephalosporin antibiotics can generally be given safely to patients who are hypersensitive to penicillin, although cross-reactions have been reported. However, this does not appear to be a significant concern with Xitil at the recommended dosage levels.
Contraindications
Do not take cefuroxime if you are known to be allergic to cephalosporins.
Pregnancy & Breastfeeding
Cefuroxime falls under US FDA pregnancy category B. That said, well-controlled studies in pregnant women are lacking, and since animal studies don't always predict how humans will respond, this medicine should only be used in pregnancy when clearly necessary. Cefuroxime does pass into breast milk, so it should be used with caution in nursing mothers.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Storage
Keep Cefuroxime Axetil in a cool, dry place, below 30° C, and away from light and moisture. Keep it out of the reach of children.
Common questions about Sefur 125 mg
What is Sefur 125 mg Powder For Suspension?
Sefur 125 mg Powder For Suspension is a medicine that contains Cefuroxime Axetil. It is made by Opsonin Pharma Limited. It belongs to the Second generation cephalosporins group of medicines.
What is Sefur used for?
Sefur is used for: Chronic Obstructive Pulmonary Disease, Bronchitis, Sinusitis, Pharyngitis, Tonsillitis, Bacterial Infection, Respiratory Tract Infection, Otitis Media.
What are the side effects of Sefur?
Adverse reactions to Xitil have not been common, and when they do occur, they tend to be mild and short-lived. Skin rashes and stomach or bowel upset have been reported.
Can I take Sefur during pregnancy or while breastfeeding?
Cefuroxime falls under US FDA pregnancy category B. That said, well-controlled studies in pregnant women are lacking, and since animal studies don't always predict how humans will respond, this medicine should only be used in pregnancy when clearly necessary. Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
How should I store Sefur?
Keep Cefuroxime Axetil in a cool, dry place, below 30° C, and away from light and moisture. Keep it out of the reach of children.
Do I need a prescription for Sefur?
Sefur is a prescription (Rx) medicine. Take it as your doctor advises.