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Other brands with the same active ingredient
These brands contain the same active ingredient (Mirtazapine). Same strength and form. Confirm the switch with your doctor or pharmacist.
Indications & Uses
Rapine 15 F/C is indicated for:
Pharmacology
Pharmacodynamics: Nobody knows exactly how Mirtazapine works, and this is true of many other medicines used to treat major depressive disorder. Studies done before human use suggest that Mirtazapine increases the activity of noradrenaline and serotonin in the central nervous system. These studies show that Mirtazapine blocks central presynaptic α2-adrenergic inhibitory autoreceptors and heteroreceptors, and this is thought to lead to more noradrenergic and serotonergic activity in the brain. Mirtazapine is a strong blocker of 5-HT2 and 5-HT3 receptors but has no meaningful affinity for the 5-HT1A and 5-HT1B receptors. It is also a strong blocker of histamine (H1) receptors, which may account for its marked sedative effect. Outside the brain, Mirtazapine moderately blocks peripheral α1-adrenergic receptors, which may explain the occasional drop in blood pressure on standing that has been reported with its use. Its moderate action on muscarinic receptors may be the reason anticholinergic side effects are fairly uncommon with this medicine.
Pharmacokinetics: After Mirtazapine tablets are taken by mouth, the active ingredient, mirtazapine, is absorbed quickly and well, and reaches its peak plasma level in about 2 hours. About 85% of mirtazapine binds to plasma proteins. The mean elimination half-life is 20 to 40 hours (26 hours in males and 37 hours in females), which is long enough to allow once-a-day dosing. Within the recommended dose range, mirtazapine's pharmacokinetics are linear. The body breaks Mirtazapine down extensively, and it is cleared through the urine and faeces over four days. The main routes of biotransformation are demethylation and oxidation, followed by conjugation.
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
The usual starting dose of mirtazapine tablets for adults is 15 mg a day, taken once, preferably in the evening or just before sleep. Most people are treated with a dose between 15 and 45 mg a day. If there is no response at 15 mg, the dose may be raised to 30 mg, and up to a maximum of 45 mg a day.
Mirtazapine stays in the body for a long time, with an elimination half-life of about 20 to 40 hours. Because of this, the dose should not be changed more often than every 1 to 2 weeks. That gap gives the body enough time to show its response to a given dose.
Mirtazapine is not recommended for use in children.
If you miss a dose of mirtazapine, take it as soon as you remember, unless it is nearly time for the next dose. If it is close to the time of the next dose, skip the missed one and take the next dose at the usual time. Never take a double dose or more than the dose your doctor has prescribed.
Side Effects
The most common side effects of Mirez (mirtazapine) are dizziness, drowsiness, dry mouth, increased appetite and weight gain, among others.
Cautions & Contraindications
Warnings & Precautions
Patients, their families and their caregivers should be encouraged to watch for anxiety, agitation, panic attacks, insomnia, irritability, hostility, aggressiveness, impulsivity, akathisia (psychomotor restlessness), hypomania, mania, other unusual changes in behavior, worsening of depression, and suicidal ideation. This matters most early in antidepressant treatment and whenever the dose is adjusted up or down. Patients who are going to receive Mirez should be warned about the risk of developing agranulocytosis. Because of its prominent sedative effect, Mirez may impair judgment, thinking and, particularly, motor skills. Clinically significant ALT (SGPT) elevations (≥3 times the upper limit of the normal range) may occur.
Contraindications
Hypersensitivity: Mirtazapine should not be used by anyone with a known hypersensitivity to Mirtazapine or to any of its excipients. Monoamine Oxidase Inhibitors: Mirtazapine must not be taken together with a monoamine oxidase (MAO) inhibitor. It should also be avoided within 14 days of starting or stopping treatment with an MAOI.
Pregnancy & Breastfeeding
Pregnancy Category C. Patients on Mirtazapine should tell their doctor right away if they become pregnant, are planning a pregnancy, or are breastfeeding an infant.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Storage
Keep away from light and moisture. Store below 30º C. Keep all medicine out of the reach of children.
Drug Interactions
Common questions about Rapine 15 F/C 15 mg
What is Rapine 15 F/C 15 mg Tablet?
Rapine 15 F/C 15 mg Tablet is a medicine that contains Mirtazapine. It is made by Advanced Chemical Industries PLC. It belongs to the Atypical anti-depressant drugs group of medicines.
What is Rapine 15 F/C used for?
Rapine 15 F/C is used for: Depression.
What are the side effects of Rapine 15 F/C?
The most common side effects of Mirez (mirtazapine) are dizziness, drowsiness, dry mouth, increased appetite and weight gain, among others.
Can I take Rapine 15 F/C during pregnancy or while breastfeeding?
Pregnancy Category C. Patients on Mirtazapine should tell their doctor right away if they become pregnant, are planning a pregnancy, or are breastfeeding an infant. Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
How should I store Rapine 15 F/C?
Keep away from light and moisture. Store below 30º C.
Can I take other medicines with Rapine 15 F/C?
Some medicines can interact with Mirtazapine, for example: Carbamazepine, Venlafaxine, Linezolid, Cimetidine, Diazepam, St. John's Wort. Tell your doctor or pharmacist about every medicine you take.
Do I need a prescription for Rapine 15 F/C?
Rapine 15 F/C is a prescription (Rx) medicine. Take it as your doctor advises.