Pricing
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All price changes →Ramoril Plus
Rx2.5 mg+12.5 mg • Tablet
Indications & Uses
Protace-H tablet is indicated for the treatment of mild to moderate hypertension in patients (in whom combination therapy is appropriate) who have been stabilised on the individual components given in the same proportion.
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
A patient whose blood pressure is not adequately controlled with Ramipril (or another ACE inhibitor) alone or with Hydrochlorothiazide (or another thiazide diuretic) alone may be switched to this combination therapy. The usual starting dose is one tablet once daily. If necessary, the dose may be increased to two tablets once daily.
Side Effects
Ramipril can cause profound hypotension and renal impairment and a persistent dry cough. It may also cause angioedema (onset may be delayed), rash (which may be associated with pouritus and urticaria), pancreatitis and upper respiratory-tract symptoms such as sinusitis, and rhinitis. Gastro-intestinal effects reported with ACE inhibitors include nausea, vomiting. dyspepsia, diarrhoea and constipation. Altered liver function tests, cholestatic jaundice and hepatitis have been reported.Blood disorders including thronbocytopenia, leucopenia, neutropenia and haemolytic anaemia have also been reported. Other reported side-effects include headache, dizziness, fatigue, taste disturbance, bronchospasm, fever, and photosensitivity. Hydrochlorothiazide can cause tachycardia, serum sickness, weight loss, maculopapular rash, photosensitivity, flushing and acidosis.
Cautions & Contraindications
Warnings & Precautions
This should be used with caution in patients with impaired renal function, hyperkalemia, hypotension, surgery/ anesthesia and impaired hepatic function.
Contraindications
This preparation must not be used in patients with hypersensitivity to ramipril, hydrochlorothiazide or other thiazide diuretics. History of hereditary angioneurotic oedema. Severe impairment of renal function. Haemodynamically relevant unilateral or bilateral renal artery stenosis, mitral stenosis, aortic stenosis, and in patients with low blood pressure (hypotensive patients) or in patients with an unstable circulatory situation (haemodynamically unstable patients) where there might be a risk of life-threatening fall in blood pressure and renal failure. Clinically relevant electrolyte disturbances e.g. hypokalemia, hyponatremia or hypercalcemia which may worsen following treatment.