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These brands contain the same active ingredient (Tenofovir Disoproxil). Same strength and form. Confirm the switch with your doctor or pharmacist.
Indications & Uses
In combination with other antiretroviral agents, for the treatment of HIV-1 infection. Tenoviral is also indicated for the treatment of chronic hepatitis B in adults.
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
The size and frequency of the dosage must be adjusted to the needs of the individual patient. Tenofovir disoproxil 245 mg oral tablets should be administered once daily orally, without regard to food. Recommended Dose in Adults: For the treatment of HIV-1 or chronic hepatitis B: The dose is 245 mg Tenofovir tablet once daily taken orally, without regard to food. In the treatment of chronic hepatitis B, the optimal duration of treatment is unknown. Recommended Dose in Pediatric Patients (12 years of age and older and greater than or equal to 35 kg): For the treatment of HIV-1 in pediatric patients 12 years of age and older with body weight greater than or equal to 35 kg: The dose is one 245 mg Tenofovir tablet once daily taken orally, without regard to food.
Side Effects
As with any medicine, side effects are possible with Tenoviral. If side effects do occur, in most cases, they are minor and either require no treatment or can easily be treated by you or your healthcare provider. Headache, diarrhea, nausea, and weakness appear to be some of the most common side effects of Tenoviral. Other possible side effects include indigestion or heartburn, chest pain, and drowsiness. While most Tenoviral side effects are minor, there are a number of side effects that should be reported to your healthcare provider immediately, including high cholesterol or triglycerides, kidney problems, depression, and anxiety.
Cautions & Contraindications
Warnings & Precautions
Lactic acidosis/severe hepatomegaly with steatosis: Lactic acidosis and severe hepatomegaly with steatosis, including fatal cases, have been reported with the use of nucleoside analogs, including Tenoviral, in combination with other antiretrovirals. A majority of these cases have been in women. Exacerbation of hepatitis after discontinuation of treatment discontinuation of anti-HBV therapy, including Tenoviral, may be associated with severe acute exacerbations of hepatitis. Patients infected with HBV who discontinue Tenoviral should be closely monitored with both clinical and laboratory follow-up for at least several months after stopping treatment. New onset or worsening renal impairment: Tenoviral is principally eliminated by the kidney. Renal impairment, including cases of acute renal failure and Fanconi syndrome (renal tubular injury with severe hypophosphatemial), has been reported with the use of Tenoviral.Coadministration with other products: Tenoviral should not be used in combination with the fixed-dose combination products which contains Tenoviral. Tenoviral should not be administered in combination with adefovir disoproxil.Patients Coinfected with HIV-1 and HBV: Due to the risk of development of HIV-1 resistance Tenoviral should only be used in HIV-1 and HBV coinfected patients as part of an appropriate antiretroviral combination regimen. Fat Redistribution In HIV-infected patients redistribution/accumulation of body fat including central obesity, dorsocervical fat enlargement buffalo hump), peripheral wasting, facial wasting, breast enlargement have been observed in patients receiving combination antiretroviral.Immune Reconstitution/Redistribution Syndrome: Immune reconstitution syndrome has been reported in HIV-infected patients treated with combination antiretroviral therapy, including Tenoviral.
Contraindications
Broken bone due to disease or illness, enlarged fatty liver, severe liver disease, acute kidney disease, decreased calcification or density of bone, a mother who is producing milk and breastfeeding, low amount of phosphate in the blood, increased blood acidity due to high levels of lactic acid and overweight.