Indications & Uses
Proston is indicated to helps in the induction of labor, and widens the cervix for easy delivery. It is also used to initiate an abortion at about 12 to 20 weeks of pregnancy and also indicated to help clean out the vagina after a miscarriage.
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
For adult patients, the recommended dose of Dinoprostone gel is 0.5 mg. After the gel is placed, the patient should remain lying on her back for 10 to 15 minutes to minimize gel leakage. In geriatrics (patients over 65 years of age), Dinoprostone gel has not been studied and is not recommended for use. In pediatrics (patients under 18 years of age), Dinoprostone gel has not been studied and is not recommended for use.
Side Effects
Common: Abnormal labor affecting the fetus, disorders of the fetal heart rate, fetal distress syndrome, and uterine hypertonus (overly strong or frequent contractions). Uncommon: Nausea, vomiting, fever, abdominal pain, and diarrhea. Rare: Disseminated intravascular coagulation, rupture of the uterus, and anaphylactic (severe allergic) reaction.
Cautions & Contraindications
Warnings & Precautions
Caution is advised when giving Proston Gel to patients with hypertonus, sustained uterine contractility, or fetal distress; hypertonic uterine contractility or tetanic uterine contractions; asthma; glaucoma; heart diseases; or depression.
Contraindications
Dinoprostone Gel should not be used in patients with known hypersensitivity to the drug or to any ingredient in the formulation, or in those for whom oxytocic drugs are unsuitable or in whom prolonged uterine contractions would be inappropriate. It should also be avoided in women with a history of cesarean section or major uterine surgery, a significant degree of cephalopelvic disproportion, or a history of difficult labor and/or traumatic delivery. Additional situations where its use is not appropriate include grand multiparae with six or more previous term pregnancies, suspected or clinically evident pre-existing fetal distress, and overdistention of the uterus such as from multiple pregnancy or polyhydramnios. It should not be given if the amniotic membranes have ruptured or chorioamnionitis is suspected, if there is unexplained vaginal bleeding during the pregnancy, or if fetal malpresentation is present. Other contraindications include gynecological, obstetrical, or medical conditions that rule out vaginal delivery; a history of epilepsy; and pregnancies complicated by an abnormal position of the placenta or umbilical cord.