Posac Injection for IV Infusio
Rx300 mg • Injection
Indications & Uses
Posac Injection for IV Infusio is indicated for:
Pharmacology
Posaconazole blocks the synthesis of ergosterol, a key component of the fungal cell membrane. It inhibits the cytochrome P-450 dependent enzyme Lanosterol 14-α-demethylase responsible for the conversion of lanosterol to ergosterol in the fungal cell membrane. This results in an accumulation of methylated sterol precursors and a depletion of ergosterol within the cell membrane, thus weakening the structure and function of the fungal cell membrane.
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
Posaconazole Tablets can be taken with or without food. The tablets should be swallowed whole with water and should not be crushed, chewed, or broken.Loading Dose: 300 mg (3 Tablets) twice a day on the first day.Maintenance Dose: 300 mg (3 Tablets) once a day from the second day.Duration of therapy should be based on the severity of the underlying disease, recovery from immunosuppression and clinical response.
Side Effects
Common treatment-emergent adverse reactions in studies with Posanox are diarrhea, nausea, fever, vomiting, headache, coughing and hypokalemia.
Cautions & Contraindications
Contraindications
Posaconazole is contraindicated in persons with known hypersensitivity to Posaconazole or other azole antifungal agents. Co-administration with ergot alkaloids, CYP3A4 substrates, Terfenadine, Astemizole, Cisapride, Pimozide, Halofantrine or Quinidine since this may result in increased plasma concentrations of these medicinal products leading to QTc prolongation and rare occurrences of torsades de pointes, HMG-CoA reductase inhibitors simvastatin, lovastatin and atorvastatin is contraindicated.
Pregnancy & Breastfeeding
Posaconazole must not be used during pregnancy unless the benefit to the mother clearly outweighs the potential risk to the fetus. Breast-feeding must be stopped on initiation of treatment with this drug.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Use in Special Populations
Pediatric Use: Safety and effectiveness in pediatric patients below the age of 13 years has not been established. Therefore, Posaconazole is not recommended for pediatric patients less than 13 years of age.
Geriatric Use: No dose adjustment is necessary for geriatric patients.
Hepatic Impairment: Posaconazole should be used with caution in patients with hepatic impairment due to limited clinical experience and the possibility that Posaconazole plasma levels may be higher in these patients. Liver function tests should be evaluated at the start of and during the course of Posaconazole therapy.
Renal Impairment: No dose adjustment is required in patients with mild (eGFR: 50-80 mL/min/1.73 m2) to moderate renal impairment (eGFR: 20-49 mL/min/1.73 m2). Patients with severe renal impairment should be monitored closely for breakthrough fungal infections.
Storage
Store below 25°C. Keep out of the reach of children.
Drug Interactions
Common questions about Posac Injection for IV Infusio 300 mg
What is Posac Injection for IV Infusio 300 mg Injection?
Posac Injection for IV Infusio 300 mg Injection is a medicine that contains Posaconazole. It is made by Advanced Chemical Industries PLC. It belongs to the Aural Anti-fungal preparations group of medicines.
What is Posac Injection for IV Infusio used for?
Posac Injection for IV Infusio is used for: Cancer.
What are the side effects of Posac Injection for IV Infusio?
Common treatment-emergent adverse reactions in studies with Posanox are diarrhea, nausea, fever, vomiting, headache, coughing and hypokalemia.
Can I take Posac Injection for IV Infusio during pregnancy or while breastfeeding?
Posaconazole must not be used during pregnancy unless the benefit to the mother clearly outweighs the potential risk to the fetus. Breast-feeding must be stopped on initiation of treatment with this drug. Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
How should I store Posac Injection for IV Infusio?
Store below 25°C. Keep out of the reach of children.
Can I take other medicines with Posac Injection for IV Infusio?
Some medicines can interact with Posaconazole, for example: Palbociclib, Olaparib, Venetoclax, Brigatinib, Regorafenib Monohydrate, Carbamazepine. Tell your doctor or pharmacist about every medicine you take.
Do I need a prescription for Posac Injection for IV Infusio?
Posac Injection for IV Infusio is a prescription (Rx) medicine. Take it as your doctor advises.