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Other brands with the same active ingredient
These brands contain the same active ingredient (Palbociclib). Same strength and form. Confirm the switch with your doctor or pharmacist.
Indications & Uses
Palbo-125 is indicated for:
Pharmacology
Palbociclib is an inhibitor of Cyclin-dependent kinases (CDK) 4 and 6. Cyclin D1 and CDK4/6 sit downstream of the signaling pathways that lead to cells multiplying. In Estrogen receptor (ER)-positive breast cancer cell lines, Palbociclib reduced cell proliferation by blocking the cell's progression from G1 into S phase of the cell cycle.
When breast cancer cell lines were treated with Palbociclib together with antiestrogens, retinoblastoma (RB) protein phosphorylation went down. This led to reduced E2F expression and signaling, and more growth arrest than either drug gave alone. In ER-positive breast cancer cell lines, the same combination also increased cell senescence compared to each drug alone. That effect was sustained for up to 6 days after Palbociclib was removed, and it was greater if the antiestrogen treatment was continued.
In vivo studies used a patient-derived ER-positive breast cancer xenograft model. They showed that Palbociclib combined with letrozole increased the inhibition of RB phosphorylation, downstream signaling and tumor growth, compared to each drug alone.
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
The recommended dose of Palbociclib is one 125 mg capsule taken by mouth once a day for 21 days in a row, followed by 7 days off treatment. Together these make a full cycle of 28 days. Take Palbociclib with food, and try to take it at about the same time each day. For men who are given Palbociclib together with an aromatase inhibitor, consider treatment with an LHRH agonist, following current clinical practice standards.
Recommended Dose Modification for Adverse Reactions:
Recommended Starting Dose: 125 mg/day
First Dose Reduction: 100 mg/day
Second Dose Reduction: 75 mg/day
If a dose reduction below 75 mg/day is needed, stop the treatment. Or follow the directions of the registered physician.
Use in Children:
Palbociclib is not indicated for use in children.
Side Effects
Palbociclib can cause a number of common side effects. These include a decrease in white blood cells (WBC), neutrophils and platelets, which may show up as leukopenia, neutropenia or thrombocytopenia. Infections and anemia are also common. Some people have raised AST and ALT levels. Other common effects are fatigue, weakness or lethargy, fever, nausea, vomiting and diarrhea. Hair loss, inflammation of the mouth and lips, rash and dry skin can also occur.
Overdose
There's no known antidote for Palbociclib. If someone takes too much of it, treatment is limited to general supportive measures.
⚠️ In an emergency call 999 or go to the nearest hospital emergency department.
Storage
Store Palbociclib below 30°C, and keep it away from light and moisture. Keep it out of the reach of children.
Drug Interactions
Common questions about Palbo-125 125 mg
What is Palbo-125 125 mg Capsule?
Palbo-125 125 mg Capsule is a medicine that contains Palbociclib. It is made by Drug International Ltd., Squib Road. It belongs to the Protein kinase inhibitor group of medicines.
What is Palbo-125 used for?
Palbo-125 is used for: Cancer.
What are the side effects of Palbo-125?
Palbociclib can cause a number of common side effects. These include a decrease in white blood cells (WBC), neutrophils and platelets, which may show up as leukopenia, neutropenia or thrombocytopenia.
What happens if I take too much Palbo-125?
There's no known antidote for Palbociclib. If someone takes too much of it, treatment is limited to general supportive measures. In an emergency call 999 or go to the nearest hospital emergency department.
How should I store Palbo-125?
Store Palbociclib below 30°C, and keep it away from light and moisture. Keep it out of the reach of children.
Can I take other medicines with Palbo-125?
Some medicines can interact with Palbociclib, for example: Carbamazepine, Clarithromycin, Telithromycin, Nelfinavir, Saquinavir, Ritonavir. Tell your doctor or pharmacist about every medicine you take.
Do I need a prescription for Palbo-125?
Palbo-125 is a prescription (Rx) medicine. Take it as your doctor advises.