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These brands contain the same active ingredient (Nicorandil). Strength and form may differ — confirm substitution with your doctor or pharmacist before switching.
Indications & Uses
Nictoris is indicated for:
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
Adult: The usual therapeutic range is 10 to 20 mg twice daily. The usual starting dose is 10 mg twice daily, in the morning and in the evening preferably, and should be titrated upwards in accordance with patients needs, response and tolerance up to 40 mg twice daily, if necessary. An even lower starting dose of 5 mg twice daily may be used in patients particularly prone to headache. Eldery: There are no special dosage requirements for elderly patients, but as with all medicines the lowest effective dose should be used. Nicorandil should be administered with care, using low starting dosages, in the elderly. Children: Not recommended. Nicorandil should be used with caution in patients with serious hepatic dysfunction.Hepatic Impairment: Dose reduction may be necessary.
Side Effects
Headache is common, especially when starting treatment, but it usually settles with continued use. Nicorandil can also widen skin blood vessels, causing flushing; some people notice nausea, vomiting, dizziness, or weakness. Mouth ulcers and muscle aches occur rarely. At high doses, blood pressure may drop and/or heart rate may rise. Angioedema (swelling beneath the skin) has also been reported.
Cautions & Contraindications
Warnings & Precautions
Hypovolaemia, low systolic BP, acute pulmonary oedema, or pregnancy may rule out use. May affect the ability to drive or operate machinery.
Contraindications
Nicorandil tablets should not be used by anyone who has shown hypersensitivity to Nicorandil. The medicine is also not suitable for patients in cardiogenic shock, for those with acute myocardial infarction accompanied by acute left ventricular failure and low filling pressures, or for patients with hypotension. It should not be taken together with phosphodiesterase-5 inhibitors, since combining the two can cause a serious drop in blood pressure. Warnings and precautions: Nicorandil should be used cautiously in patients who may have depleted blood volume or who have a low systolic blood pressure (below 100 mm Hg). Its use should be avoided altogether in patients with cardiogenic shock, or with acute myocardial infarction accompanied by acute left ventricular failure and low filling pressures. If mouth ulceration, stomatitis, or persistent or severe ulceration of the cheek lining develops, Nicorandil should be stopped and suitable treatment given. Patients with glaucoma should use Nicorandil with caution. Combining Nicorandil with other vasodilators, tricyclic antidepressants, or alcohol can increase their blood-pressure-lowering effect. Because therapeutic doses of Nicorandil can themselves lower blood pressure in hypertensive patients, it should, like other antianginal medicines, be prescribed carefully alongside antihypertensive drugs. Animal studies on mutagenicity and carcinogenicity have not shown any harmful effect of Nicorandil under the experimental conditions tested.