Indications & Uses
Neocafen is indicated for the treatment of apnea of prematurity.
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
Loading Dose: Dose of Caffeine Citrate-20 mg/kg. Route-Intravenous infusion (over 30 minutes) by using a syringe infusion pump. Frequency- One Time.Maintenance Dose: Dose of Caffeine Citrate-5 mg/kg. Route-Intravenous infusion (over 10 minutes) by using a syringe infusion pump. Frequency-Every 24 hours (beginning 24 hours after the loading dose).The duration of treatment of apnea of prematurity in the clinical trial was limited to 10 to 12 days. The safety and efficacy of caffeine citrate for longer periods of treatment have not been established. Vials containing visible particulate matter should be discarded. For single use only. Any unused solution should be discarded.
Side Effects
Few cases of sepsis, hemorrhage, necrotizing enterocolitis, gastritis, gastrointestinal hemorrhage, acidosis, cerebral hemorrhage, dyspnea, lung edema, dry skin, rash, skin breakdown, kidney failure were reported.
Cautions & Contraindications
Warnings & Precautions
Neocafen should be used with caution in infants with seizure disorders, cardiovascular disease and impaired renal or hepatic function. Serum concentrations of caffeine should be monitored and dose administration of Neocafen should be adjusted to avoid toxicity in this population.