Naurif

Adults:

Granisetron Injection: For chemotherapy-induced nausea and vomiting in adults, the recommended dose is 10 mcg/kg given intravenously within 30 minutes before chemotherapy is started, and only on the day(s) chemotherapy is given. It may be given intravenously either undiluted over 30 seconds or diluted with 0.9% Sodium Chloride or 5% Dextrose and infused over 5 minutes. As a general precaution, Granisetron Injection should not be mixed in solution with other drugs. In pediatric patients 2 to 16 years of age, the recommended dose is also 10 mcg/kg; pediatric patients under 2 years of age have not been studied. In geriatric patients, renal failure patients, or hepatically impaired patients, no dosage adjustment is required. For the treatment of postoperative nausea and vomiting in adults, the recommended dose for prevention is a single 1 mg dose of Granisetron diluted to 5 ml and given as a slow intravenous injection over 30 seconds, with administration completed before induction of anesthesia. For treating nausea and vomiting that has already occurred after surgery, the recommended dose is 1 mg of Granisetron given undiluted, intravenously, over 30 seconds. The safety and effectiveness of Granisetron Injection for preventing or treating postoperative nausea or vomiting have not been established in pediatric patients. As with the chemotherapy indication, no dosage adjustment is required in geriatric patients, renal failure patients, or hepatically impaired patients. Granisetron Tablet: For emetogenic chemotherapy, the recommended adult oral dose is 2 mg once daily or 1 mg twice daily. With the 2 mg once-daily regimen, two 1 mg tablets are taken up to one hour before chemotherapy. With the 1 mg twice-daily regimen, the first 1 mg tablet is taken up to one hour before chemotherapy and the second tablet 12 hours after the first. Either regimen is used only on the day(s) chemotherapy is given, and no dosage adjustment is required for elderly, renal failure, or hepatically impaired patients. For radiation-induced nausea and vomiting, whether from total body irradiation or fractionated abdominal radiation, the recommended adult oral dose is 2 mg once daily, taken as two 1 mg tablets within one hour of irradiation. There is no experience with oral Granisetron for preventing radiation-induced nausea and vomiting in pediatric patients.