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These brands contain the same active ingredient (Memantine Hydrochloride). Strength and form may differ — confirm substitution with your doctor or pharmacist before switching.
Indications & Uses
Memanto is indicated for:
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
For adults and older patients, the recommended maintenance dose of Memantine is 20 mg every day. To lower the risk of side effects, this dose should be reached through gradual upward titration, increasing by 5 mg per week over three weeks, so that the maintenance dose of 20 mg per day is reached from the start of week 4, following this dosage guideline. In week 1, the dose everyday is 5 mg (1 tablet) in the morning and no dose at night. In week 2, the dose everyday is 5 mg (1 tablet) in the morning and 5 mg (1 tablet) at night. In week 3, the dose everyday is 10 mg (2 tablets) in the morning and 5 mg (1 tablet) at night. From week 4 onwards, the dose everyday is 10 mg (2 tablets) in the morning and 10 mg (2 tablets) at night. If a dose is missed, simply wait and take the next dose at the usual time. Do not double the dose to make up for the missed one. In patients with moderate renal impairment, meaning a creatinine clearance of 30 to 49 ml per minute, the daily dose should be 10 mg, equivalent to 1 ml of solution or two downward strokes. If this is well tolerated after at least 7 days of treatment, the dose may be increased up to 20 mg per day according to the standard titration scheme described above. In patients with severe renal impairment, meaning a creatinine clearance of 5 to 29 ml per minute, the daily dose should be 10 mg, equivalent to 1 ml of solution or two downward strokes, per day. In patients with mild or moderate hepatic impairment, no dosage adjustment is needed. Memantine is not recommended for patients with severe hepatic impairment. Memantine is not recommended for children under 18 years of age, as there is not enough data on its safety and efficacy in this age group.
Side Effects
Most people who take Dementa XR tolerate it well. Side effects reported in 2% or fewer of patients include hallucinations, confusion, dizziness, headache and tiredness. Less commonly, some people notice anxiety, increased muscle stiffness, vomiting, urinary tract infections or a heightened sex drive. If you have a history of epileptic seizures, be aware that Dementa XR may slightly raise the chance of having one, so it's worth discussing this with your doctor beforehand.
Cautions & Contraindications
Warnings & Precautions
Caregivers should be told how the medicine is usually given (twice a day for doses above 5 mg) and how the dose is raised (at least one week between increases). Patients with kidney problems should have their kidney function checked regularly. Seizures: Dementa XR has not been formally studied in patients with a seizure disorder. In one clinical trial, seizures occurred in 0.2% of patients taking Dementa XR, compared with 0.5% of those taking placebo. Carcinogenesis, Mutagenesis and Impairment of Fertility: Studies have not shown any risk of cancer, genetic damage, or reduced fertility with Dementa XR use. Operating Vehicles or Machinery: Dementa XR may noticeably slow reaction time, so driving or operating machinery may not be safe while taking it.
Contraindications
Memantine Hydrochloride should not be used by patients who are known to be hypersensitive to Memantine Hydrochloride or to any of the excipients present in the formulation.