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These brands contain the same active ingredient (Mefloquine). Strength and form may differ — confirm substitution with your doctor or pharmacist before switching.
Indications & Uses
Meflon is indicated for:
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
Adult: For malaria prevention, take 1 tablet (250 mg) once a week, starting 1-2 weeks before travel to a malaria-risk area and continuing for 4 weeks after leaving it. For malaria treatment, take 5 tablets (5 x 250 mg) as a single dose (up to a maximum of 1.5 gm), or preferably split into 2 doses given 6 to 8 hours apart. Children 6 Months and Older: For malaria prevention, give about 5 mg per kg of body weight once a week (250 mg for children over 45 kg, with the dose reduced in proportion to body weight for those 45 kg or under). For malaria treatment, give 20 to 25 mg per kg of body weight, which may be split into two doses 6 to 8 hours apart to reduce the occurrence or severity of adverse reactions. Elderly Patients: No differences in response between elderly and younger patients have been identified. This medicine should be taken with food, preferably with meals and a full glass of water.
Side Effects
Among people who took Larimef to prevent malaria, the most commonly reported side effects were vomiting, dizziness, fainting, and extra heartbeats, with other complaints occurring in fewer than 1% of cases. Among those who took Larimef to treat malaria, the most commonly reported side effects were dizziness, muscle aches, nausea, fever, headache, vomiting, chills, diarrhoea, skin rash, abdominal pain, fatigue, loss of appetite, and ringing in the ears.
Cautions & Contraindications
Warnings & Precautions
Warnings: Larimef can sometimes cause psychiatric symptoms, ranging from anxiety, paranoia, and depression to hallucinations and psychotic behavior. Rare cases of suicidal thoughts and suicide have been reported, though no link to the drug has been confirmed. Larimef should be used with caution in patients with a previous history of depression. Taking Larimef together with quinine or quinidine may cause abnormal heart rhythms on ECG and may increase the risk of convulsions. Precautions: In patients with epilepsy, Larimef may increase the risk of convulsions. Caution should be exercised with activities requiring alertness and fine motor coordination, such as driving, piloting aircraft, and operating machinery. Larimef should be used with caution in patients with psychiatric disturbances. In patients with impaired liver function, elimination of Larimef may be prolonged, leading to higher plasma levels.
Contraindications
Use of Mefloquine is contraindicated in anyone known to be hypersensitive to Mefloquine or related compounds such as quinine and quinidine. It should not be given for prevention (prophylaxis) to patients who have active depression, a recent history of depression, generalized anxiety disorder, psychosis, schizophrenia or other major psychiatric conditions, or a history of convulsions.