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These brands contain the same active ingredient (Piracetam). Strength and form may differ — confirm substitution with your doctor or pharmacist before switching.
Indications & Uses
Cerebral vascular disorders and reduced cerebral blood flow: for both ischaemic and haemorrhagic acute events, and for long-term effects of these events or of cerebral atherosclerosis. Mental retardation in children: to help restore ease of social contact and interaction, support learning, and improve intellectual performance and school results. Behavioural and psychiatric problems in old age: for memory difficulties (especially with forming and recalling memories), fatigue-related adjustment problems, and disturbed psychomotor responses.
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
Adults: For cerebrocortical insufficiency disorders, the usual dose is 800 mg three times a day. For myoclonic seizures, the dose is 7.2 gm daily, increased by 4.8 gm per day every 3 to 4 days up to a maximum of 20 gm daily, given in 2 or 3 divided doses. Children: the daily dose depends on the child's body weight, at 50 mg/kg given in 3 divided doses. Once the desired results have been achieved, the initial dose should be reduced by half.
Side Effects
Nervousness, agitation, irritability, anxiety and sleep disturbances have been reported with piracetam. These affected under 5% of patients in clinical trials and tended to occur more often in older patients taking more than 2.4 g a day; in most cases, simply lowering the dose was enough to make the symptoms go away. Some people may also experience fatigue or drowsiness, and gastrointestinal issues such as nausea, vomiting, diarrhoea and stomach pain have been noted, though these occurred in 2% or fewer of patients during trials. Less commonly, symptoms such as dizziness, headache, trembling and increased sexual desire have been reported.
Cautions & Contraindications
Contraindications
Piracetam should not be used in patients with severe renal insufficiency (creatinine clearance below 20 ml/min) or hepatic impairment. Because the kidney is the principal route by which Piracetam is eliminated from the body, special care must be taken when treating patients with known renal insufficiency, and monitoring of renal function is recommended in such cases. The increase in half-life is directly related to the decrease in renal function and creatinine clearance, and this also holds true for older patients, in whom creatinine clearance depends on age. When creatinine clearance is below 60 ml/min, or serum creatinine is above 1.25 mg/100 ml, the prescribed dosage should be adjusted as follows. For a creatinine clearance of 60 to 40 ml/min, the dose should be reduced to 1/2 of the normal dose. For a creatinine clearance of 40 to 20 ml/min, the dose should be reduced to 1/4 of the normal dose.