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Other brands with the same active ingredient
These brands contain the same active ingredient (Labetalol Hydrochloride). Strength and form may differ — confirm substitution with your doctor or pharmacist before switching.
Indications & Uses
Lobet 100 is indicated for:
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
Oral, Adults: The recommended starting dose is 100 mg twice a day, whether Labetalol Hydrochloride is used alone or together with a diuretic. The usual maintenance dose is 200 to 400 mg twice daily. Patients with severe hypertension may need 1,200 to 2,400 mg per day, with or without a thiazide diuretic; dose increases should not exceed 200 mg twice daily at each step. Elderly patients: most will need only 100 to 200 mg twice daily. Injection and Infusion. Intravenous injection: When blood pressure must be lowered quickly, 50 mg is given by intravenous injection over at least one minute, and this may be repeated every five minutes until the response is satisfactory, up to a total dose of 200 mg. Intravenous infusion: the injection should be diluted with a suitable intravenous fluid to a concentration of 1 mg per ml; compatible fluids include 5% dextrose solution, 0.9% sodium chloride solution, and a mixture of sodium chloride and dextrose injection. Hypertension in pregnancy: start at 20 mg per hour, then double the rate every 30 minutes until the response is satisfactory or the rate reaches 160 mg per hour. Hypertension following acute myocardial infarction: start at 15 mg per hour and increase gradually to a maximum of 120 mg per hour, depending on blood pressure control. Hypertension after stroke: 10 to 20 mg by intravenous injection over one to two minutes, which may be repeated or doubled every 10 minutes, up to a maximum dose of 300 mg. Hypertension due to other causes: infuse at about 2 mg per minute until the response is satisfactory, then stop the infusion. The effective dose is usually 50 to 200 mg, though larger doses may be needed, especially in patients with phaeochromocytoma. Hypotensive anaesthesia: the recommended starting dose of Labetalol Injection is 10 to 20 mg intravenously, depending on the patient's age and condition. Patients in whom halothane is contraindicated usually need a higher starting dose of 25 to 30 mg. If satisfactory hypotension is not achieved after 5 minutes, further increments of 5 to 10 mg should be given until the desired blood pressure level is reached.
Side Effects
Postural hypotension can occur, so patients should avoid standing up suddenly during intravenous administration and for 3 hours afterward. Other reported effects include tiredness, weakness, headache, rashes, tingling of the scalp, difficulty passing urine, upper abdominal pain, nausea and vomiting, and liver damage.
Cautions & Contraindications
Warnings & Precautions
There have been rare reports of severe hepatocellular injury with Labecard therapy. The hepatic injury is usually reversible and has occurred after both short and long term treatment. If there is laboratory evidence of liver injury or the patient is jaundiced, Labecard therapy should be stopped and not re-started. Particular care should be taken when Labecard is to be used in patients with hepatic impairment. Labecard should be used with caution in patients with peripheral vascular disease as their symptoms may be exacerbated.
Contraindications
Labetalol should not be used by anyone with a known hypersensitivity to it. It is also not suitable for patients with second- or third-degree heart block, infranodal atrioventricular (A-V) block, uncontrolled heart failure, sick-sinus syndrome, or cardiogenic shock, and for other conditions marked by severe, prolonged low blood pressure or severe bradycardia. It should likewise be avoided in patients with bronchial asthma or other obstructive lung disorders.