Save on this medicine
Other brands with the same active ingredient
These brands contain the same active ingredient (Resmetirom). Same strength and form. Confirm the switch with your doctor or pharmacist.
Indications & Uses
Lipodes-L tablet is indicated in conjunction with diet and exercise for the treatment of adults with noncirrhotic nonalcoholic steatohepatitis (NASH) with moderate to advanced liver fibrosis (consistent with stages F2 to F3 fibrosis).
Pharmacology
Resmetirom is a partial agonist of the thyroid hormone receptor-beta (THR-β). Resmetirom produced 83.8% of the maximum response compared to triiodothyronine (T3), with an EC50 of 0.21 μM in an in vitro functional assay for THR-β activation. The same functional assay for thyroid hormone receptor alpha (THR-α) agonism showed 48.6% efficacy for Resmetirom relative to T3, with an EC50 of 3.74 pM. THR-p is the major form of THR in the liver, and stimulation of THR-β in the liver reduces intrahepatic triglycerides.
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
The recommended dose of Resmetirom is based on actual body weight. For patients weighing: <100 kg, the recommended dose is 80 mg orally once daily. >100 kg, the recommended dose is 100 mg orally once daily. Resmetirom can be administered with or without food.
Side Effects
The common side effects of Lipodes-L are: Diarrhea, Nausea, Vomiting, Abdominal pain, Dizziness, Pruritus, Constipation.
Cautions & Contraindications
Warnings & Precautions
Hepatotoxicity: Hepatotoxicity has been observed with use of Lipodes-L. Monitoring of patient is required during treatment with Lipodes-L for elevations in liver tests, for the development of liver-related adverse reactions and for sign & symptoms of hepatotoxicity. If hepatotoxicity is suspected, Lipodes-L should be discontinued and monitoring of the patient should be continued. If laboratory values return to baseline, the potential risks against the benefits of restarting Lipodes-L should be considered. If laboratory values do not return to baseline, DI-ALH or autoimmune liver disease should be considered in the evaluation of elevations in liver tests.Gallbladder-Related Adverse Reactions: In clinical trials, cholelithiasis, acute cholecystitis, and obstructive pancreatitis (gallstone) were observed in Lipodes-L-treated patients. If cholelithiasis is suspected, gallbladder diagnostic studies and appropriate clinical follow-up are indicated , If an acute gallbladder event is suspected, Lipodes-L treatmentshould be interrupted until the event is resolved.Drug Interaction with Certain Statins: An increase in exposure of Atorvastatin, Pravastatin, Rosuvastatin and Simvastatin was observed when concomitantly administered with Lipodes-L, which may increase the risk of adverse reactions related to these drugs. Dosage adjustment for certain statins is recommended.
Pregnancy & Breastfeeding
Pregnancy: There are no available data on Resmetirom use in pregnant women to evaluate for a drug associated risk of major birth defects, miscarriage, or other adverse maternal or fetal outcomes.Lactation: There is no information regarding the presence of Resmetirom in human or animal milk, the effects on the breast-fed infant, or the effects on milk production. The developmental and health benefits of breastfeeding should be considered along with the mother's clinical need for Resmetirom and any potential adverse effects on the breastfed infant from Resmetirom or from the underlying maternal condition.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Use in Special Populations
Pediatric Use: The safety and effectiveness of Resmetirom have not been established in pediatric patients.
Geriatric Use: No overall differences in effectiveness but numerically higher incidence of advers reactions have been observed in patients 65 years of age and older who received Resmetirom compared to younger adult patients.
Renal Impairment: The recommended dose of Resmetirom in patients with mild or moderate renal impairment is the same as in patients with normal kidney function. Resmetirom has not been studied in patients with severe renal impairment.
Hepatic Impairment: Use of Resmetirom in patients with decompensated cirrhosis (consistent with moderate to severe hepatic impairment) should be avoided. Moderate or severe hepatic impairment (Chiid-Pugh Class B or C) may increase the risk of adverse reactions of Resmetirom. No dose adjustment is recommended for patients with mild hepatic impairment (Child-Pugh Class A).
Storage
Store below 30°C, in a cool and dry place. Keep away from light. Keep out of the reach of children.
Drug Interactions
Common questions about Livheal 80 FC 80 mg
What is Livheal 80 FC 80 mg Tablet?
Livheal 80 FC 80 mg Tablet is a medicine that contains Resmetirom. It is made by Aristopharma Limited.
What is Livheal 80 FC used for?
Lipodes-L tablet is indicated in conjunction with diet and exercise for the treatment of adults with noncirrhotic nonalcoholic steatohepatitis (NASH) with moderate to advanced liver fibrosis (consistent with stages F2 to F3 fibrosis).
What are the side effects of Livheal 80 FC?
The common side effects of Lipodes-L are: Diarrhea, Nausea, Vomiting, Abdominal pain, Dizziness, Pruritus, Constipation.
Can I take Livheal 80 FC during pregnancy or while breastfeeding?
Pregnancy: There are no available data on Resmetirom use in pregnant women to evaluate for a drug associated risk of major birth defects, miscarriage, or other adverse maternal or fetal outcomes.Lactation: There is no information regarding the presence of Resmetirom in human or animal milk, the effects on the breast-fed infant, or the effects on milk production. The developmental and health benefits of breastfeeding should be considered along with the mother's clinical need for Resmetirom and any potential adverse effects on the breastfed infant from Resmetirom or from the underlying maternal condition. Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
How should I store Livheal 80 FC?
Store below 30°C, in a cool and dry place. Keep away from light.
Can I take other medicines with Livheal 80 FC?
Some medicines can interact with Resmetirom, for example: Cyclosporine, Gemfibrozil, Pioglitazone, Atorvastatin, Rosuvastatin, Clopidogrel. Tell your doctor or pharmacist about every medicine you take.
Do I need a prescription for Livheal 80 FC?
Livheal 80 FC is a prescription (Rx) medicine. Take it as your doctor advises.