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Other brands with the same active ingredient
These brands contain the same active ingredient (Levetiracetam). Same strength and form. Confirm the switch with your doctor or pharmacist.
Indications & Uses
Levetiracetam 250 mg is indicated for:
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
Dosage
Adults and adolescents from 16 years of age: The recommended starting dose is 250 mg twice daily, increased to an initial therapeutic dose of 500 mg twice daily after two weeks. The dose can be raised further by 250 mg twice daily every two weeks according to clinical response, up to a maximum of 1500 mg twice daily.
Adults (18 years and above) and adolescents (12 to 17 years) weighing 50 kg or more: The initial therapeutic dose is 500 mg twice daily, and this dose can be started from the first day of treatment. Depending on clinical response and tolerability, the daily dose can be increased up to 1,500 mg twice daily. Dose changes should be made in steps of 500 mg twice daily, increasing or decreasing every two to four weeks.
Pediatric population: The tablet formulation is not suitable for infants and children under 6 years of age; the oral solution is the preferred formulation for this group. The available tablet strengths are also not appropriate for starting treatment in children weighing less than 25 kg, for patients who cannot swallow tablets, or for giving doses below 250 mg. In all these situations, the oral solution should be used instead.
Monotherapy: The safety and efficacy of levetiracetam as monotherapy in children and adolescents below 16 years have not been established.
Add on therapy: The oral solution is the preferred formulation for infants and children under 6 years of age. For children aged 6 years and above, the oral solution should be used for doses under 250 mg, for doses that are not exact multiples of 250 mg and so cannot be given accurately with whole tablets, and for patients unable to swallow tablets. The lowest effective dose should always be used. A child or adolescent weighing 25 kg should start at 250 mg twice daily, with a maximum dose of 750 mg twice daily. For children weighing 50 kg or more, dosing follows the same schedule as in adults.
Add on therapy for infants aged from 1 month to less than 6 months: The oral solution is the formulation to use in this age group.
Side Effects
Most common adverse reactions (occurring in ≥5% of patients and more often than with placebo) include: In adult patients: sleepiness, weakness, infection, and dizziness. In pediatric patients: fatigue, aggression, stuffy nose, reduced appetite, and irritability.
Cautions & Contraindications
Warnings & Precautions
Renal impairment: Patients with kidney problems may need a lower dose of Erata. In people with severely impaired liver function, the doctor should check kidney function before choosing the dose. Acute kidney injury: Erata has very rarely been linked with acute kidney injury. This can appear anywhere from a few days to several months after treatment starts. Blood cell counts: Rarely, blood cell counts have fallen (neutropenia, agranulocytosis, leucopenia, thrombocytopenia and pancytopenia) in people taking Erata. This usually happens early in treatment. A complete blood cell count is advised for patients who feel very weak, have fever, get infections again and again, or have problems with blood clotting. Suicide: Suicide, suicide attempts, suicidal thoughts and suicidal behaviour have been reported in people taking anti-epileptic medicines, Erata included. A combined review of randomised placebo-controlled trials of anti-epileptic medicines found a small increase in the risk of suicidal thoughts and behaviour. The reason for this risk is not known. So patients should be watched for signs of depression, suicidal thoughts or suicidal behaviour, and suitable treatment should be considered. Patients, and the people who look after them, should seek medical advice if any of these signs appear. Paediatric population: The tablet form is not suitable for infants and children under 6 years of age. The data available in children did not show any effect on growth or puberty. However, the long-term effects on learning, intelligence, growth, hormone function, puberty and the ability to have children in later life are still unknown.
Contraindications
Hypersensitivity to levetiracetam, to other pyrrolidone derivatives, or to any of the other ingredients in this medicine is a contraindication to its use.
Pregnancy & Breastfeeding
Levetiracetam isn't generally recommended during pregnancy, and women of childbearing age who aren't using contraception should avoid it unless there's a clear clinical need. The drug does pass into human breast milk, so breastfeeding isn't recommended either. That said, if a mother needs to continue levetiracetam while breastfeeding, the decision should weigh the treatment's benefits and risks against the value of breastfeeding itself. Animal studies haven't shown any effect on fertility, but since no clinical data exist in humans, the actual risk to people remains unknown.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Use in Special Populations
Levetiracetam doses should be adjusted in elderly patients (65 years and older) whose kidney function is compromised. The same goes for renal impairment in general, where the daily dose must be individualized according to renal function.
In hepatic impairment, patients with mild to moderate disease need no dose adjustment. In severe hepatic impairment, the creatinine clearance may underestimate renal insufficiency. So when the creatinine clearance is less than 60 ml/min, a 50% reduction of the daily maintenance dose of levetiracetam is recommended.
Overdose
Levetiracetam overdose has caused somnolence, agitation, aggression, a depressed level of consciousness, respiratory depression and coma. After an acute overdose, the stomach may be emptied by gastric lavage or by inducing vomiting. There is no specific antidote for Levetiracetam. Treatment is symptomatic and may include haemodialysis, and the dialyser extraction efficiency is 60 % for Levetiracetam and 74% for its primary metabolite.
⚠️ In an emergency call 999 or go to the nearest hospital emergency department.
Storage
Keep Levetiracetam in a cool, dry place where the temperature doesn't go above 25°C, and keep it away from light.
Drug Interactions
Common questions about Levetiracetam 250 mg 250 mg
What is Levetiracetam 250 mg 250 mg Tablet?
Levetiracetam 250 mg 250 mg Tablet is a medicine that contains Levetiracetam. It is made by Incepta Pharmaceuticals Ltd. (Dhamrai Unit). It belongs to the Adjunct anti-epileptic drugs group of medicines.
What is Levetiracetam 250 mg used for?
Levetiracetam 250 mg is used for: Epilepsy.
What are the side effects of Levetiracetam 250 mg?
Most common adverse reactions (occurring in ≥5% of patients and more often than with placebo) include: In adult patients: sleepiness, weakness, infection, and dizziness. In pediatric patients: fatigue, aggression, stuffy nose, reduced appetite, and irritability.
Can I take Levetiracetam 250 mg during pregnancy or while breastfeeding?
Levetiracetam isn't generally recommended during pregnancy, and women of childbearing age who aren't using contraception should avoid it unless there's a clear clinical need. The drug does pass into human breast milk, so breastfeeding isn't recommended either. Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
What happens if I take too much Levetiracetam 250 mg?
Levetiracetam overdose has caused somnolence, agitation, aggression, a depressed level of consciousness, respiratory depression and coma. After an acute overdose, the stomach may be emptied by gastric lavage or by inducing vomiting. In an emergency call 999 or go to the nearest hospital emergency department.
How should I store Levetiracetam 250 mg?
Keep Levetiracetam in a cool, dry place where the temperature doesn't go above 25°C, and keep it away from light.
Can I take other medicines with Levetiracetam 250 mg?
Some medicines can interact with Levetiracetam, for example: Brivaracetam, Methotrexate. Tell your doctor or pharmacist about every medicine you take.
Do I need a prescription for Levetiracetam 250 mg?
Levetiracetam 250 mg is a prescription (Rx) medicine. Take it as your doctor advises.