Pricing
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All price changes →Indications & Uses
Laxibat is indicated for:
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
The usual adult dose for oral use is 10 mg once daily as Elobixibat before meal. The dosage may be adjusted depending on the patient's symptoms but must not exceed the highest dose of 15 mg per day.Use in the elderly: Since the elderly generally have reduced physiological functions, cautions should be exercised, such as reducing the dose.Use in children: Safety has not been established in low-birth-weight infants, neonates, nursing infants, infants, or pediatric patients (no clinical experience).
Side Effects
Generally, Laxibat is well tolerated in patients with chronic constipation. In clinical studies, the side effects include abdominal pain, diarrhea, nausea, abdominal discomfort, soft faeces, abdominal distension, liver function test abnormalities. If liver function test anomalies are detected, patient’s symptoms should be monitored carefully, if necessary, Laxibat should be discontinued.
Cautions & Contraindications
Warnings & Precautions
Precaution concerning indication: No clinical experience of use in drug-induced and disease-induced constipations. Precaution concerning dosage and administration: Laxibat may cause abdominal pain or diarrhea; dose reduction, drug withdrawal, or discontinuation should be considered depending on the patient's symptoms. The need for continuing treatment with Laxibat should be carefully evaluated on a regular basis to avoid continuing aimless administration.Careful administration: In patients with serious liver disorder, Laxibat may fail to achieve its expected efficacy due to biliary obstruction or reduced bile acid secretion, etc.
Contraindications
Hypersensitivity to the active substance or to any of the excipients. Patients with a documented intestinal obstruction associated with a tumor or hernia or with the suspicion of such conditions. Intestinal obstruction may be aggravated.