Kolchin

Adults:

Acute gouty arthritis: joint pain and swelling are typically reduced within 12 hours and are usually gone within 24 to 48 hours. An interval of three days between colchicine courses is advised to minimize the possibility of cumulative toxicity. The total amount of colchicine needed to control pain and inflammation during an attack usually ranges from 4 to 8 mg. First dose: 1 to 1.2 mg (two 0.6 mg tablets) at a time, then one 0.6 mg tablet every 2 hours until pain and inflammation are relieved. For prophylaxis during intercritical periods: severe cases may require two or three 0.6 mg tablets daily. For cases involving more than one attack per year, the usual dose is 0.6 mg daily. In patients who have less than one attack per year, the usual dose is 0.6 mg per day, three or four days a week. To reduce the frequency and severity of attacks, colchicine may be administered continuously. For prophylaxis against attacks of gout in patients undergoing surgery: in patients with gout, even a minor surgical procedure may bring on an attack. One 0.6 mg tablet three times daily should be given for three days before and three days after surgery.