Indications & Uses
Fulvestrant is indicated for:
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
Fulvestrant 500 mg should be administered intramuscularly into the buttocks (gluteal area) slowly (1-2 minutes per injection) as two 5 mL injections, one in each buttock, on Days 1, 15, 29, and once monthly thereafter. A dose of 250 mg is recommended in patients with moderate hepatic impairment to be administered intramuscularly into the buttock (gluteal area) slowly (1-2 minutes) as one 5 mL injection on Days 1, 15, 29, and once monthly thereafter.Pediatric Use: Safety and effectiveness in pediatric patients have not been established.
Side Effects
The most common adverse reactions occurring in ≥5% of patients receiving Faslodex 500 mg were: injection site pain, nausea, bone pain, arthralgia, headache, back pain, fatigue, pain in extremity, hot flash, vomiting, anorexia, asthenia, musculoskeletal pain, cough, dyspnea, and constipation.Increased hepatic enzymes (ALT, AST, ALP) occurred in >15% of Faslodex patients and were not dose-dependent.
Cautions & Contraindications
Warnings & Precautions
Risk of Bleeding: Use with caution in patients with bleeding diatheses, thrombocytopenia, or anticoagulant use.Increased Exposure in Patients with Hepatic Impairment: Use a 250 mg dose for patients with moderate hepatic impairment.Injection Site Reaction: Use caution while administering Faslodex at the dorsogluteal injection site due to the proximity of the underlying sciatic nerve.Embryo-Fetal Toxicity: Can cause fetal harm. Advise females of reproductive potential of the potential risk to a fetus and to use effective contraception.Immunoassay Measurement of Serum Estradiol: Faslodex can interfere with estradiol measurement by immunoassay, resulting in falsely elevated estradiol levels.