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Other brands with the same active ingredient
These brands contain the same active ingredient (Clomiphene Citrate). Strength and form may differ — confirm substitution with your doctor or pharmacist before switching.
Indications & Uses
Fermid is indicated for:
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
For females: 50 mg is taken once daily for 5 days. This can begin on any day from the second to the fifth day of the menstrual cycle if bleeding is occurring, or at any time if the patient has had no recent uterine bleeding. A smaller dose or a shorter course may be needed for patients who are unusually sensitive to clomiphene, such as those with polycystic ovary syndrome. If ovulation does not occur, the dose is raised to 75-100 mg daily for 5 days, with the next course starting no sooner than 30 days after the previous one. Generally, three courses are enough to determine whether ovulation can be achieved; if it still has not occurred, the diagnosis should be reassessed. If ovulation occurs without conception, the same cycle is repeated until conception happens or for 3-4 cycles. If pregnancy has not occurred after about 6 cycles in total, continuing clomiphene therapy is not recommended. For males: 25 mg is taken once daily for up to 90 days, with a 5-day break recommended after every 25 days of treatment. Patients on haemodialysis: Haemodialysis shortens the serum half-life by 25-30%. Patients on regular haemodialysis are given a loading dose of 250 mg-1 g before dialysis. Elderly: Dosing is the same as for adults. Time to peak effect: Ovulation usually occurs 4-10 days after the last day of treatment, averaging around 7 days, though this can vary between patients and cycles. In rare cases, it may occur as late as 14 days after treatment ends.
Side Effects
At the recommended dosage, side effects are generally uncommon. How often they occur, and how severe they are, tends to depend on the dose and how long treatment lasts, and they usually resolve once clomiphene is stopped. Reported effects include visual disturbances, ovarian hyperstimulation, hot flushes, abdominal discomfort, and occasionally nausea, vomiting, depression, insomnia, breast tenderness, headache, spotting between periods, heavy menstrual bleeding, endometriosis, convulsions, weight gain, rashes, dizziness, and hair loss. Doses above 100 mg a day for five days carry a greater risk of side effects, so patients on these doses should be monitored closely. Rare cases of ovarian cancer have been reported with fertility drugs, but no causal link has been established, since infertility itself is already a major risk factor for the disease.
Cautions & Contraindications
Warnings & Precautions
Ovulet should be used only under medical supervision, with clomiphene therapy started after patients have been carefully selected. A complete pelvic examination is essential before treatment begins and must be repeated before each subsequent course, to rule out pregnancy, ovarian enlargement, or ovarian cyst formation between cycles. When conception occurs during clomiphene therapy, the chance of a multiple pregnancy is higher.
Contraindications
Pregnancy, liver insufficiency, abnormal vaginal bleeding (uterine tumour, ovarian cyst).