Pricing
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All price changes →Indications & Uses
Extals tablet is indicated to extend life or the time to mechanical ventilation for patients with amyotrophic lateral sclerosis (A progressive neurological disorder).
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
The recommended daily dose of Riluzole tablet in adults or older people is 100mg (50mg tablet every 12 hours). Riluzole tablet should be taken at least one hour before, or two hours after a meal, to avoid a decrease in Riluzole bioavailability.Paediatric use: Riluzole is not recommended for use in paediatric population.
Side Effects
Nausea, abnormal liver function tests, asthenia, headache, dizziness, oral paraesthesia, somnolence, tachycardia, diarrhoea, abdominal pain, vomiting, pain, anaemia, allergic reactions, angioedema, pancreatitis, interstitial lung disease.
Cautions & Contraindications
Warnings & Precautions
Liver impairment: Extals should be prescribed with care in patients with a history of abnormal liver function, or in patients with slightly elevated serum transaminases (ALT/SGPT; AST/SGOT up to 3 times the upper limit of the normal range (ULN)), bilirubin and/or gamma-glutamyl transferase (GGT) levels. Baseline elevations of several liver function tests (especially elevated bilirubin) should preclude the use of Extals.Because of the risk of hepatitis, serum transaminases, including ALT, should be measured before and during therapy with Extals. ALT should be measured every month during the first 3 months of treatment, every 3 months during the remainder of the first year, and periodically thereafter. ALT levels should be measured more frequently in patients who develop elevated ALT levels. Extals should be discontinued if the ALT levels increase to 5 times the ULN.Renal impairment: Extals is not recommended for use in patients with impaired renal function. Neutropenia: Patients should be warned to report any febrile illness to their physicians. In case of neutropenia, Extals should be discontinued.Interstitial lung disease: Cases of interstitial lung disease have been reported in patients treated with Extals. In case of interstitial lung disease, Extals should be discontinued immediately.Effects on ability to drive and use machines: Patients should be warned about the potential for dizziness or vertigo, and advised not to drive or operate machinery if these symptoms occur.
Contraindications
Hypersensitivity to the active substance or to any of the excipients. Hepatic disease or baseline transaminases greater than 3 times the upper limit of normal.