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These brands contain the same active ingredient (Pivmecillinam). Strength and form may differ — confirm substitution with your doctor or pharmacist before switching.
Indications & Uses
Emcil is indicated for:
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
Adults: The usual dose is 1-2 tablets 3 times daily according to the severity of the infection. In acute uncomplicated cystitis: initially 400 mg, then 200 mg every 8 hours for 3 days. In chronic or recurrent bacteriuria: 400 mg every 6 to 8 hours. For the treatment of salmonellosis (including enteric fever): 1.2 to 2.4 gm daily for 14 days. To eliminate salmonella carriage, therapy may be prolonged for 2 to 4 weeks. In complicated urinary tract infection, the usual treatment time is 1 to 2 weeks. For prophylactic treatment of recurrent urinary tract infections, 1 tablet every evening is recommended. Children: The usual dose is as follows. Those weighing less than 20 kg should be given 20 to 60 mg/kg divided into 3 to 4 daily doses. Those weighing more than 20 kg should receive the normal adult dose. In shigellosis: 20 mg/kg 4 times a day for 5 days. For urinary tract infection (UTI): 20 to 40 mg/kg/day in 3 to 4 divided doses. For salmonellosis: 30 to 60 mg/kg/day in 3 to 4 divided doses. The tablet should be taken with at least 50 to 100 ml of fluid. Since this tablet's bioavailability is practically unaffected by simultaneous food intake, this tablet is best taken with or immediately after a meal.
Side Effects
Pivcilin is generally well tolerated, even by patients with reduced kidney function. Upper gastrointestinal disturbances such as nausea, vomiting and diarrhoea or indigestion may occur when a dose has been taken on an empty stomach. Skin rashes have been reported in some cases, but the characteristic ampicillin rash has never been observed, nor has there been any evidence of liver, kidney, or ear toxicity. The occurrence of anaphylaxis, though not yet reported, cannot be entirely ruled out.
Cautions & Contraindications
Warnings & Precautions
Since mecillinam (the active form of pivmecillinam) is cleared from the body mainly by the kidneys, patients with reduced kidney function may build up higher blood levels of the drug if doses are repeated, as with other antibiotics handled the same way.
Contraindications
There have been no reports on allergy to Pivmecillinam among patients with a known history of hypersensitivity to penicillins and cephalosporins. Nevertheless, it seems reasonable to exclude such patients from treatment with Pivmecillinam until further experience has been gained.