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Same active ingredient — pay up to 50% less
These brands contain the same active ingredient (Roflumilast). Same strength and form. Confirm the switch with your doctor or pharmacist.
More from Dilarof
Other strengths and forms by Unimed Unihealth Pharmaceuticals Ltd.
Indications & Uses
Dilarof is indicated for:
Pharmacology
Roflumilast is a phosphodiesterase-4 (PDE-4) inhibitor. By selectively inhibiting the PDE4 isoenzyme, it exerts potential anti-inflammatory and antimodulatory effects within the pulmonary system. It is thought that the resulting rise in intracellular cyclic AMP levels is responsible for Roflumilast's therapeutic actions.
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
Adult dose: The recommended dose is one tablet of 500 micrograms Roflumilast, taken once daily. It may need to be taken for several weeks before its full effect is felt, and clinical trials have followed its use for up to one year.
For elderly patients aged 65 years and older, no dose adjustment is necessary. Patients with renal impairment likewise need no dose adjustment.
Patients with mild hepatic impairment, classified as Child Pugh A, have limited clinical data available, so Roflumilast should be used with caution in these cases and a dose adjustment cannot currently be recommended. Patients with moderate or severe hepatic impairment, classified as Child Pugh B or C, must not take Roflumilast.
Roflumilast has no relevant use in the pediatric population under 18 years of age.
The tablet should be swallowed with water at the same time every day, and it can be taken with or without food.
Side Effects
Rofusis is usually well tolerated. Some people notice side effects such as reduced appetite and weight loss, trouble sleeping, headache, diarrhoea, nausea, or stomach discomfort.
Cautions & Contraindications
Warnings & Precautions
Rofusis contains an active ingredient that some patients need to be counselled about before starting therapy. Not a rescue medicine: Rofusis works as an anti-inflammatory agent, so it should not be used to relieve a sudden asthma or bronchospasm attack. Weight loss: In year-long studies, patients taking Rofusis lost weight more often than those on placebo. Most who stopped the medicine had regained the lost weight within three months. Underweight patients should have their weight checked at every visit, and all patients should weigh themselves regularly. If weight loss is unexplained and becomes a concern, Rofusis should be stopped and the patient's weight monitored further. Special health conditions: Because there is not enough experience to guide safe use, Rofusis should not be started, or should be stopped if already in use, in patients with serious immune-related diseases (such as HIV infection, multiple sclerosis, lupus, or progressive multifocal leukoencephalopathy), severe acute infections, cancers other than basal cell carcinoma, or in those taking immune-suppressing medicines such as methotrexate, azathioprine, infliximab, etanercept, or long-term oral corticosteroids (short courses of systemic corticosteroids are not included). There is limited experience in patients with dormant infections such as tuberculosis, viral hepatitis, herpes, or shingles. Rofusis has not been studied in patients with congestive heart failure of NYHA class 3 or 4, so its use is not recommended in this group. Mental health effects: Rofusis can raise the risk of mental health problems such as insomnia, anxiety, nervousness, and depression. Rare cases of suicidal thoughts and behaviour, including completed suicide, have occurred in patients with or without a prior history of depression, usually within the first few weeks of treatment. If a patient reports past or current psychiatric symptoms, or is also taking other medicines that can cause such effects, the doctor should carefully weigh the benefits and risks before starting or continuing Rofusis. It is not recommended for patients with a history of depression linked to suicidal thoughts or behaviour. Patients and caregivers should be told to report any change in mood or behaviour, or any suicidal thoughts, to the prescriber right away. Treatment should be stopped if new or worsening psychiatric symptoms, suicidal thoughts, or a suicide attempt occur. Persistent side effects: Side effects such as diarrhoea, nausea, stomach pain, and headache usually appear in the first few weeks of treatment and tend to ease with continued use. If they persist and remain hard to tolerate, treatment with Rofusis should be reviewed. This is more likely in groups with higher drug exposure, such as black, nonsmoking women, or patients also taking the CYP1A2 inhibitor fluvoxamine, or dual CYP3A4/1A2 inhibitors such as enoxacin and cimetidine. Theophylline: There is no clinical evidence supporting the use of Rofusis together with theophylline as maintenance therapy, so this combination is not recommended. Lactose: Rofusis tablets contain lactose. Patients with rare hereditary conditions such as galactose intolerance, Lapp lactase deficiency, or glucose-galactose malabsorption should not take this medicine.
Contraindications
Do not use Roflumilast if you are allergic to it or to any of its other ingredients. It should also be avoided if you have moderate to severe liver problems.
Pregnancy & Breastfeeding
Pregnancy: There isn't much data yet on using Roflumilast during pregnancy. Animal studies have shown effects on reproduction, and the drug has been shown to cross the placenta in pregnant rats. For this reason, Roflumilast is not recommended for pregnant women or for women who could become pregnant and are not using contraception.
Breastfeeding: In animal studies, Roflumilast and its breakdown products have been found in milk, so a risk to a nursing infant cannot be ruled out. Roflumilast should not be used while breastfeeding.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Overdose
In Phase I studies, people who took Roflumilast as a single oral dose of 2,500 micrograms, or one single dose of 5,000 micrograms (ten times the recommended dose), reported certain symptoms more often. These were headache, gastrointestinal disorders, dizziness, palpitations, light-headedness, clamminess and arterial hypotension.
If an overdose happens, appropriate supportive medical care is recommended. Roflumilast is highly protein bound, so haemodialysis is not likely to remove it efficiently. Whether Roflumilast can be removed by peritoneal dialysis is not known.
⚠️ In an emergency call 999 or go to the nearest hospital emergency department.
Storage
Store Roflumilast below 30° C. Keep it away from light and moisture, and keep it out of the reach of children.
Drug Interactions
Common questions about Dilarof 500 mcg
What is Dilarof 500 mcg Tablet?
Dilarof 500 mcg Tablet is a medicine that contains Roflumilast. It is made by Unimed Unihealth Pharmaceuticals Ltd. It belongs to the Antihistamines anti-allergies & hypo-sensitisation group of medicines.
What is Dilarof used for?
Dilarof is used for: Chronic Obstructive Pulmonary Disease, Bronchitis.
What are the side effects of Dilarof?
Rofusis is usually well tolerated. Some people notice side effects such as reduced appetite and weight loss, trouble sleeping, headache, diarrhoea, nausea, or stomach discomfort.
Can I take Dilarof during pregnancy or while breastfeeding?
Pregnancy: There isn't much data yet on using Roflumilast during pregnancy. Animal studies have shown effects on reproduction, and the drug has been shown to cross the placenta in pregnant rats. Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
What happens if I take too much Dilarof?
In Phase I studies, people who took Roflumilast as a single oral dose of 2,500 micrograms, or one single dose of 5,000 micrograms (ten times the recommended dose), reported certain symptoms more often. These were headache, gastrointestinal disorders, dizziness, palpitations, light-headedness, clamminess and arterial hypotension. In an emergency call 999 or go to the nearest hospital emergency department.
How should I store Dilarof?
Store Roflumilast below 30° C. Keep it away from light and moisture, and keep it out of the reach of children.
Can I take other medicines with Dilarof?
Some medicines can interact with Roflumilast, for example: Salbutamol, Pyrimethamine, Dapsone, Ethanol 70%, Betahistine Mesilate. Tell your doctor or pharmacist about every medicine you take.
Is there a cheaper medicine with the same ingredient?
Romilast by Labaid Pharmaceuticals Ltd. has the same ingredient and strength for ৳10.00 per unit, compared with ৳20.00 for Dilarof. Ask your doctor or pharmacist before switching.
Do I need a prescription for Dilarof?
Dilarof is a prescription (Rx) medicine. Take it as your doctor advises.