Pricing
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These brands contain the same active ingredient (Gliclazide). Strength and form may differ — confirm substitution with your doctor or pharmacist before switching.
Indications & Uses
Diaprid is indicated for:
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
Film-coated tablet: The usual initial dose is 40 to 80 mg daily. The dose can be increased up to 320 mg daily in divided doses when needed. The drug should be taken before meal. For children, Gliclazide is not used because it is contraindicated in juvenile-onset diabetes.Modified release preparation: Always take this medicine exactly as your doctor or pharmacist has told you. Check with your doctor or pharmacist if you are not sure. The dose is determined by the doctor, depending on your blood and possibly urine sugar levels. Change in external factors (weight reduction, lifestyle, stress) or improvements in the blood sugar control may require changed gliclazide doses.The recommended daily dose is one to four tablets (maximum 120 mg) in a single intake at breakfast time. This depends on the response to treatment. Gliclazide MR tablet is for oral use. Take your tablet(s) with a glass of water at breakfast time (and preferably at the same time each day). Swallow your whole tablet(s) in one piece. Do not chew or crush. You must always eat a meal after taking your tablet(s).If a combination therapy of gliclazide with metformin, an alpha-glucosidase inhibitor, a thiazolidinedione, a dipeptidyl peptidase-4 inhibitor a GLP-1 receptor agonist or insulin is initiated your doctor will determine the proper dose of each medicine individually for you. If you notice that your blood sugar levels are high although you are taking the medicine as prescribed, you should contact your doctor or pharmacist.If you take more Gliclazide tablets than you should: If you take too many tablets, contact your doctor or the nearest hospital Accident & Emergency department immediately. The signs of overdose are those of low blood sugar (hypoglycaemia). The symptoms can be helped by taking sugar (4 to 6 lumps) or sugary drinks straight away, followed by a substantial snack or meal. If the patient is unconscious immediately inform a doctor and call the emergency services. The same should be done if somebody, (for instance a child), has taken the product unintentionally. Unconscious patients must not be given food or drink. It should be ensured that there is always a pre-informed person that can call a doctor in case of emergency.If you forget to take Gliclazide tablet: It is important to take your medicine every day as regular treatment works better. However, if you forget to take a dose of Gliclazide MR tablet, take the next dose at the usual time. Do not take a double dose to make up for a forgotten dose.If you stop taking Gliclazide MR tablet: As the treatment for diabetes is usually lifelong, you should discuss with your doctor before stopping this medicinal product. Stopping could cause high blood sugar (hyperglycaemia) which increases the risk of developing complications of diabetes. If you have any further questions on the use of this product, ask your doctor or pharmacist.
Side Effects
Like all medicines, Glicron CR can cause side effects, although not everybody gets them. The most commonly observed side effect is low blood sugar (hypoglycaemia). If left untreated, these symptoms could progress to drowsiness, loss of consciousness or possibly coma. If an episode of low blood sugar is severe or prolonged, even if it is temporarily controlled by eating sugar, you should seek immediate medical attention. Liver disorders: There have been isolated reports of abnormal liver function, which can cause yellow skin and eyes. If you notice this, see your doctor immediately. The symptoms generally disappear once the medicine is stopped, and your doctor will decide whether to stop your treatment. Skin disorders: Skin reactions such as rash, redness, itching, hives, blisters, and angioedema (rapid swelling of tissues such as the eyelids, face, lips, mouth, tongue or throat that may cause breathing difficulty) have been reported. A rash may progress to widespread blistering or peeling of the skin. If this develops, stop taking the medicine and seek urgent advice from a doctor, letting them know you are taking it. In rare cases, signs of a severe hypersensitivity reaction have been reported, starting with flu like symptoms and a rash on the face, then spreading into an extended rash with a high temperature. Blood disorders: A decrease in the number of certain blood cells (such as platelets, red blood cells and white blood cells) has been reported, which may cause paleness, prolonged bleeding, bruising, sore throat and fever. These symptoms usually go away once treatment is stopped. Digestive disorders: Abdominal pain, nausea, vomiting, indigestion, diarrhoea and constipation may occur. These effects are reduced when Glicron CR is taken with a meal, as recommended. Eye disorders: Your vision may be affected for a short time, especially at the start of treatment. This is due to changes in blood sugar levels. As with other sulfonylureas, the following effects have also been observed: severe changes in blood cell counts, allergic inflammation of the blood vessel walls, a drop in blood sodium levels (hyponatraemia), and signs of liver impairment such as jaundice, which in most cases resolve after the sulfonylurea is stopped but may, in isolated cases, lead to life threatening liver failure. Reporting of side effects: If you get any side effects, talk to your doctor or pharmacist. This includes any side effects not listed here. Reporting side effects helps provide more information on the safety of this medicine.
Cautions & Contraindications
Warnings & Precautions
Talk to your doctor before taking Glicron CR. You should observe the treatment plan prescribed by your doctor to achieve proper blood sugar levels. This means, apart from regular tablet intake, observing the dietary regimen, taking physical exercise and, where necessary, reducing weight. During Glicron CR treatment, regular monitoring of your blood (and possibly urine) sugar level and also your glycated haemoglobin (HbA1c) is necessary. In the first few weeks of treatment, the risk of having reduced blood sugar levels (hypoglycaemia) may be increased, so particularly close medical monitoring is necessary. Low blood sugar (hypoglycaemia) may occur if you take meals irregularly or skip meals altogether, if you are fasting, if you are malnourished, if you change your diet, if you increase your physical activity and your carbohydrate intake does not match this increase, if you drink alcohol, especially in combination with skipped meals, if you take other medicines or natural remedies at the same time, if you take too high doses of Glicron CR, if you suffer from particular hormone induced disorders such as functional disorders of the thyroid gland, pituitary gland or adrenal cortex, or if your kidney function or liver function is severely decreased. If you have low blood sugar, you may notice symptoms such as headache, intense hunger, nausea, vomiting, weariness, sleep disorders, restlessness, aggressiveness, poor concentration, reduced alertness and reaction time, depression, confusion, speech or visual disorders, tremor, sensory disturbances, dizziness and helplessness. The following signs and symptoms may also occur: sweating, clammy skin, anxiety, fast or irregular heartbeat, high blood pressure, and sudden strong pain in the chest that may radiate into nearby areas, known as angina pectoris. If blood sugar levels continue to drop, you may suffer from considerable confusion (delirium), develop convulsions, lose self control, your breathing may become shallow and your heartbeat may slow down, and you may become unconscious. In most cases the symptoms of low blood sugar vanish very quickly when you consume some form of sugar, for instance glucose tablets, sugar cubes, sweet juice or sweetened tea. You should therefore always carry some form of sugar with you, such as glucose tablets or sugar cubes. Remember that artificial sweeteners are not effective. Please contact your doctor or the nearest hospital if taking sugar does not help or if the symptoms recur. Symptoms of low blood sugar may be absent, less obvious or develop very slowly, or you may not become aware in time that your blood sugar level has dropped. This may happen if you are an elderly patient taking certain medicines, for instance those acting on the central nervous system and beta blockers. If you are in stressful situations such as accidents, surgical operations or fever, your doctor may temporarily switch you to insulin therapy. Symptoms of high blood sugar (hyperglycaemia) may occur when Glicron CR has not yet sufficiently reduced the blood sugar, when you have not complied with the treatment plan prescribed by your doctor, if you take St. John's Wort (Hypericum perforatum) preparations, or in special stress situations. These may include thirst, frequent urination, dry mouth, dry itchy skin, skin infections and reduced performance. Blood glucose disturbances, meaning both low blood sugar and high blood sugar, can occur when Glicron CR is prescribed at the same time as medicines from a class of antibiotics called fluoroquinolones, especially in elderly patients. In this case, your doctor will remind you of the importance of monitoring your blood glucose. If you have a family history of, or know you have, the hereditary condition glucose-6-phosphate dehydrogenase (G6PD) deficiency, an abnormality of red blood cells, lowering of the haemoglobin level and breakdown of red blood cells (haemolytic anaemia) can occur. Contact your doctor before taking this medicinal product. Glicron CR is not recommended for use in children due to lack of data.
Contraindications
Do not take Gliclazide if you are allergic to gliclazide, to other sulfonylurea medicines, or to related hypoglycaemic sulfonamides. It should also be avoided if you have insulin-dependent (type 1) diabetes, if you have ketone bodies and sugar in your urine (which may signal diabetic ketoacidosis), a diabetic pre-coma or coma, or severe kidney or liver disease. You should not take this medicine if you are being treated with antifungal medicines, or if you are breastfeeding.