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Hyperphosphatemia in Chronic Kidney Disease Patient.
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
Sucroferric Oxyhydroxide tablets should be chewed or crushed. Do not swallow whole. The recommended starting dose of Dephos is 3 tablets (1,500 mg) per day, administered as 1 tablet (500 mg) 3 times daily with meals. Monitor serum phosphorus levels and titrate the dose of Sucroferric Oxyhydroxide in decrements or increments of 500 mg (1 tablet) per day as needed until an acceptable serum phosphorus level is reached, with regular monitoring afterwards. Titrate as often as weekly. Sucroferric Oxyhydroxide must be administered with meals. To maximize the dietary phosphate binding, distribute the total daily dose among meals. No additional fluid above the amount usually taken by the patient is required. If one or more doses of DephosrM are missed, the medication should be resumed with the next meal. Do not attempt to replace a missed dose.Pediatric use: The safety and efficacy of Sucroferric Oxyhydroxide have not been established in pediatric patients.
Side Effects
The most common adverse drug reactions to Dephos chewable tablets in hemodialysis patients included discolored feces (12%) and diarrhea (6%).
Cautions & Contraindications
Warnings & Precautions
Monitoring in Patients with Gastrointestinal Disorders or Iron Accumulation Disorders: Patients with peritonitis during peritoneal dialysis, significant gastric or hepatic disorders, following major gastrointestinal (Gl) surgery, or with a history of hemochromatosis or other diseases with iron accumulation have not been included in clinical studies with Dephos. Monitor effect and iron homeostasis in such patients.