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These brands contain the same active ingredient (Etoricoxib). Strength and form may differ — confirm substitution with your doctor or pharmacist before switching.
Indications & Uses
Danilo is indicated for:
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
Adults and adolescents over 16 years: Osteoarthritis: The usual dose is 30 mg once daily. If symptoms are not adequately relieved, the dose may be increased to 60 mg once daily. Rheumatoid arthritis: The usual dose is 90 mg once daily. Ankylosing spondylitis: The usual dose is 90 mg once daily. Acute gouty arthritis: The usual dose is 120 mg once daily. In clinical trials, this dose was given for 8 days at a time. Postoperative dental surgery pain: The usual dose is 90 mg once daily, for no more than 3 days. Some patients may need additional pain relief after surgery. Because the cardiovascular risks of Etoricoxib can increase with higher doses and longer use, it should be taken at the lowest effective dose for the shortest time needed. Doctors should periodically reassess whether continued treatment is still needed and how well it is working, particularly for patients being treated for osteoarthritis.
Side Effects
Side-effects that have been reported with etoricoxib include palpitations, tiredness, flu-like symptoms, and easy bruising. Less commonly, it may cause dry mouth, a change in taste, mouth ulcers, changes in appetite or weight, an irregular heartbeat (atrial fibrillation), a transient ischaemic attack ("mini-stroke"), chest pain, flushing, cough, breathlessness, nosebleeds, anxiety, reduced mental sharpness, tingling or numbness, disturbances in blood electrolyte levels, and muscle or joint pain. Very rarely, it may cause confusion or hallucinations.
Cautions & Contraindications
Warnings & Precautions
Caution is advised when treating patients most at risk of gastrointestinal complications from NSAIDs, including elderly patients, those taking another NSAID or acetylsalicylic acid at the same time, or those with a prior history of gastrointestinal disease such as ulceration and GI bleeding. Patients with significant cardiovascular risk factors (for example, hypertension, high cholesterol, diabetes, or smoking) should be treated with Ezepain only after careful consideration. Ezepain can reduce prostaglandin formation and, in turn, renal blood flow, which may impair kidney function; monitoring of renal function should be considered in such patients. Caution should also be used in patients with a history of heart failure, left ventricular dysfunction, or hypertension, and in those with pre-existing fluid retention from any cause. Patients showing symptoms or signs of liver problems, or an abnormal liver function test, should be monitored closely. If signs of liver impairment appear, or if liver function tests remain abnormal at three times the upper limit of normal, Ezepain should be stopped. Treatment should also be discontinued at the first sign of skin rash, mucosal lesions, or any other symptom of hypersensitivity. Ezepain may mask fever and other signs of inflammation, so this should be kept in mind during evaluation. Finally, caution is needed when Ezepain is taken together with warfarin or other oral anticoagulants.
Contraindications
Hypersensitivity to the active substance or to any of the excipients. Active peptic ulcer disease or active gastrointestinal (GI) bleeding. A history of bronchospasm, acute rhinitis, nasal polyps, angioneurotic oedema, urticaria, or other allergic-type reactions after taking acetylsalicylic acid or NSAIDs, including COX-2 (cyclooxygenase-2) inhibitors. Pregnancy and breastfeeding. Severe liver impairment (serum albumin below 25 g/L, or a Child-Pugh score of 10 or above). Estimated renal creatinine clearance below 30 ml/min. Children and adolescents under 16 years of age. Inflammatory bowel disease. Congestive heart failure (NYHA class II-IV). Hypertension where blood pressure remains persistently above 140/90 mmHg despite treatment. Established ischaemic heart disease, peripheral arterial disease, and/or cerebrovascular disease.