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Same active ingredient — pay up to 17% less
These brands contain the same active ingredient (Sacubitril + Valsartan). Same strength and form. Confirm the switch with your doctor or pharmacist.
Indications & Uses
Covista is indicated for:
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
Adult Heart Failure: The recommended starting dose is 49/51 mg orally twice daily. Double the dose after 2 to 4 weeks to the target maintenance dose of 97/103 mg twice daily, as tolerated by the patient.Reduce the starting dose to 24/26 mg twice daily for: Patients not currently taking an angiotensin-converting enzyme inhibitor (ACEi) or an angiotensin II receptor blocker (ARB) or previously taking a low dose of these agents. Patients with severe renal impairment. Patients with moderate hepatic impairment. Pediatric Heart Failure: Refer to Table 1 for the recommended dose for pediatric patients aged one year and older. Take the recommended dose orally twice daily. Adjust pediatric patient doses every 2 weeks, as tolerated by the patient.Recommended Dose Titration-Pediatric Patients Less than 40 kg: Starting: 1.6 mg/kg Second: 2.3 mg/kg Final: 3.1 mg/kg Pediatric Patients At least 40 kg, less than 50 kg: Starting: 24/26 mg Second: 49/51 mg Final: 49/51 mg Pediatric Patients At least 50 kg: Starting: 49/51 mg Second: 72/78 mg Final: 97/103 mg
Side Effects
The most common side effects are Angioedema, Hypotension, Impaired Renal Function, Hyperkalemia, Cough, Dizziness.
Cautions & Contraindications
Warnings & Precautions
This tablet may cause angioedema and must not be used in patients with a known history of angioedema related to previous ACEi or ARB therapy and in patients with hereditary angioedema.This tablet lowers blood pressure and may cause symptomatic hypotension. Closely monitor serum creatinine, and down-titrate or interrupt this tablet in patients who develop a clinically significant decrease in renal function. In patients with renal artery stenosis, monitor renal function.Monitor serum potassium periodically and treat appropriately, especially in patients with risk factors for hyperkalemia such as severe renal impairment, diabetes, hypoaldosteronism, or a high potassium diet. Dosage reduction or interruption of this tablet may be required.
Contraindications
This combination is contraindicated: In patients with hypersensitivity to any component In patients with a history of angioedema related to previous ACE inhibitor or ARB therapy With concomitant use of ACE inhibitors. Do not administer within 36 hours of switching from or to an ACE inhibitor With concomitant use of aliskiren in patients with diabetes