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These brands contain the same active ingredient (Sulindac). Strength and form may differ — confirm substitution with your doctor or pharmacist before switching.
Indications & Uses
Clinorel is indicated for:
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
Sulindac is taken by mouth twice a day with food. The maximum dose is 400 mg per day; doses above 400 mg per day are not recommended. For osteoarthritis, rheumatoid arthritis and ankylosing spondylitis, the recommended starting dose is 150 mg. For acute painful shoulder and acute gouty arthritis, the recommended dose is 200 mg twice a day. The dose may be lowered or raised depending on the response. Once a satisfactory response has been achieved, the dose may be reduced according to the response. Or, as directed by a registered physician.
Side Effects
Stomach and bowel problems are the most common side effects of sulindac. These include abdominal pain, nausea and constipation. Ulcers and bleeding in the stomach or gut can also occur. The side effects most often reported on the nervous system are drowsiness, dizziness, headache and nervousness. Other side effects that may occur include depression, ringing in the ears (tinnitus), confusion, light-headedness, difficulty sleeping, psychiatric disturbances, fainting, convulsions, coma, nerve damage in the hands or feet (peripheral neuropathy), blurred vision and other eye problems, fluid retention and weight gain, high blood pressure, blood in the urine, skin rashes, itching, hives, mouth sores, hair loss and allergic (hypersensitivity) reactions. A hypersensitivity syndrome has also been reported. It may involve fever and chills, skin rashes or other skin changes, liver damage, kidney damage (including kidney failure), low white blood cell count (leukopenia), low platelet count (thrombocytopenia), raised eosinophil count, swollen glands or lymph nodes, and joint pain. Further reported effects include low white blood cell count, purpura (purple spots from bleeding under the skin), low platelet count, aplastic anaemia, haemolytic anaemia, agranulocytosis (a severe drop in certain white blood cells), nosebleeds, high blood sugar, high blood potassium and vaginal bleeding. There have also been reports of hepatitis, jaundice and kidney failure.
Cautions & Contraindications
Warnings & Precautions
Sulinzen should be used with caution in patients with impaired kidney function, bleeding disorders, epilepsy, parkinsonism or psychiatric disorders. In patients with liver impairment, the half-life of Sulinzen is prolonged and a reduction in the daily dose may be needed. Anaemia is sometimes seen in patients receiving NSAIDs together with Sulinzen.
Contraindications
Sulindac should not be used by people who are allergic to it, or by those who have had an acute asthma attack, hives (urticaria) or a runny nose (rhinitis) triggered by aspirin or other non-steroidal anti-inflammatory drugs. It is also not suitable for people with a history of active gastrointestinal bleeding or peptic ulcers. Sulindac should not be given to children, or to women who are pregnant or breastfeeding.