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These brands contain the same active ingredient (Cefaclor Monohydrate). Strength and form may differ — confirm substitution with your doctor or pharmacist before switching.
Indications & Uses
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
Capsule: Adult dose: The usual dose is 250 mg every 8 hourly. For severe infections or those caused by less susceptible organisms, doses may be doubled with a maximum dosage of 4 g/day. In case of β-hemolytic Streptococcal infections, therapy should be administered for at least 10 days.Powder for suspension & Pediatric drops: Children: The usual daily dosage for paediatric patients over 1 month is 20 mg/kg/day in divided doses every 8 hours. In serious infections such as otitis media and infections caused by less susceptible organisms, 40 mg/kg/day are recommended, with a maximum dosage of 1 g/day. Safety and effectiveness of Cefaclor for use in infants less than 1 month of age have not been established.<1 year (9 kg): Powder for suspension: ½ tsp three times daily Pediatric drops: 0.625 ml three times daily 1-5 years (9 kg-18 kg): Powder for suspension: 1 tsp three times daily Pediatric drops: 1.25 ml three times daily Over 5 years: Powder for suspension: 2 tsp three times daily In renal impairment: Cefaclor may be administered in the presence of impaired renal function. Dose adjustments for patients with moderate or sever renal impairment are not usually required.In patients undergoing haemodialysis: Haemodialysis shortens serum half-life by 25-30%. In patients undergoing haemodialysis, a predialysis loading dose of 250 mg-1 g is recommended. A maintaining dose of 250-500 mg every 6 hourly during interdialytic period may be used.Geriatric use: Clinical experience has not identified differences in responses between the elderly and younger patients, but greater sensitivity of some older individuals cannot be ruled out.
Side Effects
Gastro-intestinal symptoms may occur include diarrhea, nausea and vomiting in some patients receiving CFL. As with some penicillins and some other Cephalosporins, transient hepatitis and cholestatic jaundice have been reported rarely. Fever, abdominal pain, superinfection, renal dysfunction, toxic nephropathy, hemorrhage, elevated LDH and pancytopenia may occur.
Cautions & Contraindications
Warnings & Precautions
Prescribing CFL in the absence of a proven or strongly suspected bacterial infection or a prophylactic indication is unlikely to provide benefit to the patient and increases the risk of the development of drug-resistant bacteria.Prolonged use of CFL may result in the overgrowth of nonsusceptible organisms. If superinfection occurs during therapy, appropriate measures should be taken. As with other β-lactam antibiotics, the renal excretion of CFL is inhibited by Probenecid. Antibiotics, including Cephalosporins, should be prescribed with caution in individuals with a history of gastrointestinal disease, particularly colitis.Before therapy with CFL is instituted, careful inquiry should be made to determine whether the patient has had previous hypersensitivity reactions to CFL, Cephalosporins, Penicillins or other drugs. If CFL is to be given to penicillin-sensitive patients, caution should be exercised. CFL should be administered cautiously to any patient who has demonstrated some form of allergy, particularly to drugs.
Contraindications
Cefaclor is contraindicated in patients with known allergy to the Cephalosporin group of antibiotics.