Indications & Uses
Bleonix is indicated for:
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
Total doses of over 300,000 IU should be given with great caution. 10,000 to 20,000 IU/m2 of body surface area given weekly or twice weekly. Alternatively, give 15,000 IU daily for 7 days followed by three weeks off-treatment and repeat twice so that a total dose of approximately 300,000 IU is administered.Improvement of lymphomas and testicular tumours is prompt i.e. within two weeks while response by squamous cell cancers may take as long as three weeks.A therapeutic response should be observed as the total dose approaches 150,000 IU, if this is not seen, consideration should be given to other therapy.Bleomycin may be given by the intramuscular, intravenous, subcutaneous or intra-arterial routes. Because of the possibility of an anaphylactoid reaction, lymphoma patients should receive test doses of between 1-5 units, for the first two treatments. If no acute allergic reaction occurs within 4-6 hours, the balance of the dose may be given. Thereafter the regular dosage schedule may be followed, if no reaction occurs.
Side Effects
Common side effects of Bleonix include injection site reactions (pain, redness, warmth, itching, or swelling), fever, chills, vomiting, loss of appetite, weight loss, darkening or discoloration of the skin, changes in fingernails or toenails, itching, or pain near your tumor.
Cautions & Contraindications
Warnings & Precautions
It is recommended that Bleonix be administered under the supervision of a qualified physician experienced in the use of cancer chemotherapeutic agents. Appropriate management of therapy and complications is possible only when adequate diagnostic and treatment facilities are readily available. Patients receiving bleomycin must be observed carefully and frequently during and after therapy. After injection, bleomycin is readily absorbed and distributed in the body, particularly in the skin, lungs and any susceptible tumour tissue, leading to possible skin and pulmonary toxicity, as well as antitumour activity. If pulmonary changes are noted, treatment should be discontinued until it can be determined whether the cause is drug-related.
Contraindications
Bleomycin is contraindicated in patients with known allergy or idiosyncrasy to the drug. Bleomycin is also contraindicated in patients with acute pulmonary infection or greatly reduced lung function. A repeat course of therapy is contraindicated in any patient who has shown any signs of pneumonitis or decreased pulmonary function