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Other brands with the same active ingredient
These brands contain the same active ingredient (Brivaracetam). Same strength and form. Confirm the switch with your doctor or pharmacist.
Indications & Uses
Bivara 50 FC is indicated for:
Pharmacology
Brivaracetam is an anticonvulsant, and this preparation contains it. Nobody knows exactly how Brivaracetam works to control seizures. It binds strongly and selectively to synaptic vesicle protein 2A (SV2A) in the brain, and this may be part of the reason it works against seizures.
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
Brivaracetam tablet or oral solution is taken by mouth, with or without food. The recommended dose for patients 1 month of age and older is given below. In pediatric patients weighing less than 50 kg, the dosing depends on body weight. You don't need to build the dose up gradually when starting treatment. Adjust it according to clinical response and how well the patient tolerates it.
Adults (16 years and older): the initial dose is 50 mg twice daily (100 mg per day). The minimum and maximum maintenance dose is 25 mg to 100 mg twice daily (50 mg to 200 mg per day).
Pediatric patients weighing 50 kg or more: the initial dose is 25 mg to 50 mg twice daily (50 mg to 100 mg per day). The minimum and maximum maintenance dose is 25 mg to 100 mg twice daily (50 mg to 200 mg per day).
Pediatric patients weighing 20 kg to less than 50 kg: the initial dose is 0.5 mg/kg to 1 mg/kg twice daily (1 mg/kg to 2 mg/kg per day). The minimum and maximum maintenance dose is 0.5 mg/kg to 2 mg/kg twice daily (1 mg/kg to 4 mg/kg per day).
Pediatric patients weighing 11 kg to less than 20 kg: the initial dose is 0.5 mg/kg to 1.25 mg/kg twice daily (1 mg/kg to 2.5 mg/kg per day). The minimum and maximum maintenance dose is 0.5 mg/kg to 2.5 mg/kg twice daily (1 mg/kg to 5 mg/kg per day).
Pediatric patients weighing less than 11 kg: the initial dose is 0.75 mg/kg to 1.5 mg/kg twice daily (1.5 mg/kg to 3 mg/kg per day). The minimum and maximum maintenance dose is 0.75 mg/kg to 3 mg/kg twice daily (1.5 mg/kg to 6 mg/kg per day).
Geriatric use: choose the dose for an elderly patient with care, usually starting at the low end of the dosing range.
Renal impairment: patients with impaired renal function don't need a dose adjustment. Brivaracetam is not recommended in patients with end stage renal disease who are undergoing dialysis.
Use in children and adolescents: safety and effectiveness have not been established in pediatric patients below the age of 1 month.
Side Effects
The most common side effects of brivaracetam are nausea and vomiting, constipation, drowsiness and sedation, dizziness, fatigue, problems with coordination and balance (from effects on the cerebellum), and irritability.
Cautions & Contraindications
Warnings & Precautions
Antiepileptic drugs (AEDs), Brivaracetam included, raise the risk of suicidal thoughts or behavior. Anyone treated with an AED should be watched for new or worsening depression, suicidal thoughts or behavior, and any unusual change in mood or behavior. Brivaracetam causes somnolence, fatigue, dizziness and disturbance in coordination. Patients should be monitored for these signs and symptoms and advised not to drive or operate machinery. Brivaracetam also causes psychiatric adverse reactions. These include non-psychotic symptoms (irritability, anxiety, nervousness, aggression, belligerence, anger, agitation, restlessness, depression, depressed mood, tearfulness, apathy, mood swings, psychomotor hyperactivity, abnormal behavior and adjustment disorder) and psychotic symptoms (psychotic disorder along with hallucination, paranoia, acute psychosis and psychotic behavior). As with most antiepileptic drugs, Brivaracetam should generally be withdrawn gradually, because stopping it suddenly can increase seizure frequency and lead to status epilepticus.
Contraindications
Don't give brivaracetam to anyone who is known to be hypersensitive to it, or to any other ingredient in the product.
Pregnancy & Breastfeeding
Pregnancy: Brivaracetam should not be used during pregnancy unless it is clinically necessary, that is, if the benefit to the mother clearly outweighs the possible risk to the fetus.
Lactation: There are no data on whether brivaracetam passes into human milk, what it does to a breastfed infant, or whether it affects milk production. The developmental and health benefits of breastfeeding should be weighed against the mother's clinical need for brivaracetam. Any possible adverse effects on the breastfed infant should also be considered, whether they come from brivaracetam or from the mother's underlying condition.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Overdose
An overdose of Brivaracetam can cause vertigo, balance disorder, fatigue, nausea, diplopia, anxiety and bradycardia. There is no specific antidote for it. If an overdose happens, the doctor should follow the standard medical practice used for any overdose. This means making sure the airway is clear and that the person gets enough oxygen and ventilation. Monitoring of the heart rate, heart rhythm and vital signs is recommended.
⚠️ In an emergency call 999 or go to the nearest hospital emergency department.
Storage
Keep Brivaracetam in a cool, dry place, below 30°C, and away from light. Keep it out of the reach of children.
Drug Interactions
Common questions about Bivara 50 FC 50 mg
What is Bivara 50 FC 50 mg Tablet?
Bivara 50 FC 50 mg Tablet is a medicine that contains Brivaracetam. It is made by Advanced Chemical Industries PLC. It belongs to the Adjunct anti-epileptic drugs group of medicines.
What is Bivara 50 FC used for?
Bivara 50 FC is used for: Epilepsy.
What are the side effects of Bivara 50 FC?
The most common side effects of brivaracetam are nausea and vomiting, constipation, drowsiness and sedation, dizziness, fatigue, problems with coordination and balance (from effects on the cerebellum), and irritability.
Can I take Bivara 50 FC during pregnancy or while breastfeeding?
Pregnancy: Brivaracetam should not be used during pregnancy unless it is clinically necessary, that is, if the benefit to the mother clearly outweighs the possible risk to the fetus. Lactation: There are no data on whether brivaracetam passes into human milk, what it does to a breastfed infant, or whether it affects milk production. Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
What happens if I take too much Bivara 50 FC?
An overdose of Brivaracetam can cause vertigo, balance disorder, fatigue, nausea, diplopia, anxiety and bradycardia. There is no specific antidote for it. In an emergency call 999 or go to the nearest hospital emergency department.
How should I store Bivara 50 FC?
Keep Brivaracetam in a cool, dry place, below 30°C, and away from light. Keep it out of the reach of children.
Can I take other medicines with Bivara 50 FC?
Some medicines can interact with Brivaracetam, for example: Carbamazepine, Levetiracetam, Phenytoin, Rifampicin. Tell your doctor or pharmacist about every medicine you take.
Do I need a prescription for Bivara 50 FC?
Bivara 50 FC is a prescription (Rx) medicine. Take it as your doctor advises.