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These brands contain the same active ingredient (Metoprolol Tartrate). Same strength and form. Confirm the switch with your doctor or pharmacist.
More from Betaloc-XR
Other strengths and forms by Drug International Unani Ltd.
Indications & Uses
Betaloc-XR is indicated for:
Pharmacology
Metoprolol is a selective beta-1 blocker. It blunts the heart's response to catecholamines, the stress hormones released during physical or mental strain, so the usual rise in heart rate, cardiac output, contractility, and blood pressure that these hormones trigger is reduced. Compared with non-selective beta-blockers, Metoprolol has less effect on insulin release and carbohydrate metabolism, and it interferes far less with the body's cardiovascular response to low blood sugar.
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
Film-coated tablet
Hypertension: The total daily dose of Metoprolol is 100 to 400 mg, given as a single dose or twice daily. The starting dose is 100 mg (two Metoprolol-50 tablets) per day. This may be increased by 100 mg per day at weekly intervals. If full control is not achieved with a single daily dose, a b.i.d. regimen should be started. Combination therapy with a diuretic or other antihypertensive agents may also be considered.
Angina: Usually Metoprolol 50 mg (one Metoprolol-50 tablet) to 100 mg (two Metoprolol-50 tablets) twice or three times daily.
Cardiac arrhythmias: Metoprolol 50 mg (one Metoprolol-50 tablet) b.i.d or t.i.d should usually control the condition. If necessary, the dose can be increased up to 300 mg per day in divided doses. After an acute arrhythmia has been treated with Metoprolol injection, continuation therapy with Metoprolol tablets should be started 4 to 6 hours later. The initial oral dose should not exceed 50 mg t.i.d.
Hyperthyroidism: Metoprolol 50 mg (one Metoprolol-50 tablet) four times a day. The dose should be reduced once the euthyroid state is achieved.
Myocardial infarction: Oral therapy should begin 15 minutes after the last injection, with 50 mg every 6 hours for 48 hours. Patients who cannot tolerate the full intravenous dose should be given half the suggested oral dose. For maintenance, the usual dose is 200 mg daily in divided doses.
Elderly: There are no special dosage requirements in otherwise healthy elderly patients.
Significant hepatic dysfunction: A reduction in dosage may be necessary.
Extended-release tablet
Hypertension: The usual initial dose is 25 to 100 mg daily as a single dose, whether used alone or added to a diuretic.
Angina pectoris: The dose of extended-release Metoprolol Succinate should be individualized. The usual initial dose is 100 mg daily as a single dose.
Heart failure: The recommended starting dose of sustained-release Metoprolol Succinate is 25 mg once daily for two weeks in patients with NYHA class II heart failure, and 12.5 mg once daily in patients with more severe heart failure. The dose may be increased at weekly (or longer) intervals until optimum blood pressure reduction is achieved. If treatment is to be stopped, the dose should be reduced gradually over 1 to 2 weeks.
IV injection
Arrhythmias: By intravenous injection, up to 5 mg at a rate of 1 to 2 mg/minute, repeated after 5 minutes if necessary, to a total dose of 10 to 15 mg.
In surgery: By slow intravenous injection, 2 to 4 mg at induction or to control arrhythmias that develop during anaesthesia. Doses of 2 mg may be repeated to a maximum of 10 mg.
Myocardial infarction: For early intervention within 12 hours of infarction, give 5 mg by intravenous injection every 2 minutes to a maximum of 15 mg. After 15 minutes, follow with 50 mg by mouth every 6 hours for 48 hours. Maintenance is 200 mg daily in divided doses.
Side Effects
Tiredness, dizziness, low mood, diarrhea, itching or rash, shortness of breath, slow heart rate, mental confusion, headache, drowsiness, nightmares, insomnia, difficulty breathing, nausea, dry mouth, stomach pain, constipation, flatulence, digestive disturbances, heartburn, itching, muscle or joint pain, blurred vision, decreased libido, and ringing in the ears have also been reported, along with worsening of AV block.
Cautions & Contraindications
Warnings & Precautions
Bronchospastic Diseases: Because Preloc is relatively beta 1 selective, it may still be used with caution in patients with bronchospastic disease who do not respond to, or cannot tolerate, other antihypertensive treatments. Major Surgery: Whether beta blocking therapy should be withdrawn before major surgery is a matter of debate; the heart's reduced ability to respond to reflex adrenergic stimuli may increase the risks associated with general anesthesia and surgical procedures. Diabetes and Hypoglycemia: Beta blockers may mask the tachycardia that occurs with hypoglycemia, though other signs such as dizziness and sweating are usually not significantly affected. Peripheral Vascular Disease: Beta blockers can bring on or worsen symptoms of arterial insufficiency in patients with peripheral vascular disease. Calcium Channel Blockers: Because these agents can have significant effects on heart contraction and rate when combined, caution should be exercised in patients being treated with both concomitantly.
Contraindications
Contraindicated in AV block, uncontrolled heart failure, severe bradycardia, sick sinus syndrome, cardiogenic shock, and severe peripheral arterial disease, as well as in anyone with known hypersensitivity to metoprolol or other beta-blockers. It should also be avoided when a heart attack is complicated by marked bradycardia, first-degree heart block, systolic blood pressure below 100 mmHg, and/or severe heart failure.
Pregnancy & Breastfeeding
Pregnancy Category C. Well-controlled studies in pregnant women are lacking, so Metoprolol should be used in pregnancy only when the need is clear. It does pass into breast milk, though only in very small amounts, and should still be given to a nursing mother with caution.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Use in Special Populations
Hepatic impairment: Metoprolol Tartrate should be used with caution in patients with impaired liver function.
Pediatric use: In children aged 6 to 16 years, the adverse events seen were not clinically different from those in adults. Safety and effectiveness of Metoprolol Tartrate have not been established in patients under 6 years of age.
Geriatric use: Older patients and younger patients showed no notable differences in how well the medicine worked or in the rate of adverse events.
Overdose
Poisoning due to an overdose of metoprolol may lead to severe hypotension, sinus bradycardia, atrioventricular block, heart failure, cardiogenic shock, cardiac arrest, bronchospasm, impairment of consciousness, coma, nausea, vomiting, cyanosis, hypoglycaemia and, occasionally, hyperkalaemia. The first manifestations usually appear 20 minutes to 2 hours after drug ingestion. Treatment: Treatment should include close monitoring of cardiovascular, respiratory and renal function, and blood glucose and electrolytes. Further absorption may be prevented by induction of vomiting, gastric lavage or administration of activated-charcoal if ingestion is recent. Cardiovascular complications should be treated symptomatically, which may require the use of sympathomimetic agents (e.g. noradrenaline, metaramionl), atropine or inotropic agents (e.g. dopamine, dobutamine). Temporary pacing may be required for AV block. Glucagon can reverse the effects of excessive B-blockade, given in a dose of 1-10 mg intravenously. Intravenous B2-stimulants e.g. terbutaline may be required to relieve bronchospasm. Metoprolol Tartrate cannot be effectively removed by haemodialysis.
⚠️ In an emergency call 999 or go to the nearest hospital emergency department.
Storage
Store in a cool and dry place, protected from light.
Drug Interactions
Common questions about Betaloc-XR 50 mg
What is Betaloc-XR 50 mg Tablet (Extended Release)?
Betaloc-XR 50 mg Tablet (Extended Release) is a medicine that contains Metoprolol Tartrate. It is made by Drug International Unani Ltd.
What is Betaloc-XR used for?
Betaloc-XR is used for: Hypertension, Angina Pectoris, Myocardial Infarction, Pain, Hyperthyroidism.
What are the side effects of Betaloc-XR?
Tiredness, dizziness, low mood, diarrhea, itching or rash, shortness of breath, slow heart rate, mental confusion, headache, drowsiness, nightmares, insomnia, difficulty breathing, nausea, dry mouth, stomach pain, constipation, flatulence, digestive disturbances, heartburn, itching, muscle or joint pain, blurred vision, decreased libido, and ringing in the ears have also been reported, along with worsening of AV block.
Can I take Betaloc-XR during pregnancy or while breastfeeding?
Pregnancy Category C. Well-controlled studies in pregnant women are lacking, so Metoprolol should be used in pregnancy only when the need is clear. Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
What happens if I take too much Betaloc-XR?
Poisoning due to an overdose of metoprolol may lead to severe hypotension, sinus bradycardia, atrioventricular block, heart failure, cardiogenic shock, cardiac arrest, bronchospasm, impairment of consciousness, coma, nausea, vomiting, cyanosis, hypoglycaemia and, occasionally, hyperkalaemia. The first manifestations usually appear 20 minutes to 2 hours after drug ingestion. In an emergency call 999 or go to the nearest hospital emergency department.
How should I store Betaloc-XR?
Store in a cool and dry place, protected from light.
Can I take other medicines with Betaloc-XR?
Some medicines can interact with Metoprolol Tartrate, for example: Paroxetine, Fluoxetine, Lercanidipine Hydrochloride, Sodium Alginate + Sodium Bicarbonate + Calcium Carbonate, Dopamine Hydrochloride, Dextromethorphan + Phenylephrine + Triprolidine. Tell your doctor or pharmacist about every medicine you take.
Is there a cheaper medicine with the same ingredient?
Metoprol-XL by Beximco Pharmaceuticals Ltd. has the same ingredient and strength for ৳3.00 per unit, compared with ৳4.00 for Betaloc-XR. Ask your doctor or pharmacist before switching.
Do I need a prescription for Betaloc-XR?
Betaloc-XR is a prescription (Rx) medicine. Take it as your doctor advises.