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Other brands with the same active ingredient
These brands contain the same active ingredient (Baricitinib). Strength and form may differ — confirm substitution with your doctor or pharmacist before switching.
Indications & Uses
Barigen is indicated for:
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
Adult dose: The recommended dose of Baricitinib is 2 mg once daily. It may be used as monotherapy or in combination with Methotrexate or other Disease-modifying antirheumatic drugs (DMARDS). Baricitinib can be given orally with or without food.Pediatric Use: The safety and effectiveness of Baricitinib in pediatric patients have not been established.Geriatric Use: Because elderly patients are more likely to have decreased renal function, care should be taken in dose selection.Hepatic Impairment: No dose adjustment is necessary in patients with mild or moderate hepatic impairment.Renal impairment: Baricitinib is not recommended for use in patients with estimated GFR of less than 60 mL/min/I .73 m2.
Side Effects
The most commonly reported adverse drug reactions (ADRs) occurring in 2% of patients treated with Baricent monotherapy or in combination with conventional synthetic DMARDs were increased LDL cholesterol (33.6%), upper respiratory tract infections (14.7%) and nausea (2.8%).
Cautions & Contraindications
Warnings & Precautions
Serious Infections: Avoid use of Baricent in patients with an active, serious infection, including localized infections. Tuberculosis: Baricent should not be given to patients with active TB. Malignancy and Lymphoproliferative Disorders: Consider the risks and benefits of Baricent treatment prior to initiating therapy in patients with a known malignancy other than a successfully treated non-melanoma skin cancer (NMSC) or when considering continuing Baricent in patients who develop a malignancy. Thrombosis: Baricent should be used with caution in patients who may be at increased risk of thrombosis. Gastrointestinal Perforations: Baricent should be used with caution in patients who may be at increased risk for gastrointestinal perforation. To be dispensed only by the prescription of a registered physician.
Contraindications
Anemia: Avoid initiation or interrupt Baricitinib in patients with hemoglobin less than 8 g/dL. Lymphopenia: Avoid initiation or interrupt Baricitinib in patients with an Absolute Lymphocyte Count less than 500 cells/mm3. Neutropenia: Avoid initiation or interrupt Baricitinib in patients with an Absolute Neutrophil Count less than 1000 cells/mm3.